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Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to enhance processivity of telomerase. Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114064 (52 worldwide citation)

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the preparation of a medicament for enhancing the processivity of a telomerase increasing the number of mitotic cycles and mitotic cell division.


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Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to inhibit neoplasia. Institute Of Organic Chemistry And Biochemistry A Cademy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114065 (51 worldwide citation)

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the manufacture of a medicament for inhibiting an enzyme that causes neoplasia in an animal (e.g. a human) and enhancing the processivity of a telomerase.


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De Clercq Erik, Holy Antonin, Rosenberg Ivan: Purines etpyrimidines n-phosphonylmethoxyalkyliques; leur emploi a des fins therapeutiques, N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof. De Clercq Erik, Holy Antonin, Rosenberg Ivan, Stichting Rega Vzw, Institute Of Organic Chemistry And Biochemistry Of The Academy Of, BORDEN LADNER GERVAIS, December 21, 1999: CA1340856

Disclosed are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from such heterocyclic bases and their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Most of the compounds exhibit a marked antiviral acti ...


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Holy Antonin, Balzarini Jan M R, de Clercq Erik Desire Alice: (phosphonomethoxy)Alkoxy pyrimidine derivatives having antiviral activity. Acad Of Science Czech Republic, Rega Stichting, Balzarini Jan M R, Clercq Erik Desire Alice de, Holy Antonin, April 14, 2004: EP1406911-A1

Novel compounds are provided having formula (I), where R>1234<, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).


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Balzarini Jan M R, de, Clercq Erik Desire Alice, Holy Antonin: (phosphonomethoxy)Alkoxy pyrimidine derivatives having antiviral activity. Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic, Rega Stichting Vzw, Balzarini Jan M R, de, Clercq Erik Desire Alice, Holy Antonin, GABRIELOVÁ Marta, January 9, 2003: WO/2003/002580

Novel compounds are provided having formula (I), where R¿1?, R¿2?, R¿3?, R¿4?, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).


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Holy Antonin, Jindrich Jindrich: Di(2-propyl)esters of 1-fluoro-2-phosphonomethoxy-3-p-toluenesulfonyloxypropanes, their producing and utilization. Gilead Sciences, Holy Antonin, Jindrich Jindrich, MURASHIGE Kate H, November 26, 1992: WO/1992/020692

The invention relates to new compounds, di(2-propyl) esters of (R)-, (S)- and (RS)-1-fluoro-2-phosphonomethoxy-3-p-toluenesulfonyloxypropane and the method of producing them. The compounds can be used with advantage in the preparation of N-(3-fluoro-2-phosphonomethoxypropyl) derivatives of heterocyl ...


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Holy Antonin, Krecmerová Marcela, Piskala Alois, Andrei Graciela, Snoeck Robert, de, Clercq Erik, Neyts Johan, Naesens Lieve: Azacytosine derivatives useful as antiviral agents. Ku Leuven Research & Development, Institute Of Organic Chemistry And Biochemistry Ofacademy Of Sciences Of The Czech Republic, Holy Antonin, Krecmerová Marcela, Piskala Alois, Andrei Graciela, Snoeck Robert, de, Clercq Erik, Neyts Johan, Naesens Lieve, sBIRD Ariane, June 14, 2007: WO/2007/065231

The present invention provides 5-azacytosine derivatives with antiviral activity, specifically having viral replication inhibiting properties, more particularly in DNA viruses such as pox-, papilloma- and herpes viruses in humans. The invention also provides pharmaceutical compositions comprising su ...


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Holy Antonin, Otmar Miroslav, Piskala Alois: Method of manufacturing 1-(2-deoxy-alpha-d-erythro-pentofuranosyl)-5-azacytosine. Ustav Organicke Chemie A Biochemie Av Cr Vvi, Holy Antonin, Otmar Miroslav, Piskala Alois, GABRIELOVA Marta, August 28, 2008: WO/2008/101448

This invention relates to a method of manufacturing 1-(2-deoxy-alpha-D-erythro-pentofuranosyl)-5-azacytosine by the treatment of protected alkyl or aralkyl 2-deoxy-D-erythro-pentofuranoside with silylated 5-azacytosine in the presence of Lewis acid and subsequent removal the protecting groups.



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