1
Rainer Alex, Paul Hadvary, Hansjorg Tschirky: Dermally affixed injection device. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, August 3, 1999: US05931814 (484 worldwide citation)

An improved injection device has a casing containing an active substance reservoir, a cannula communicating with the reservoir, a device for inserting the cannula, and pump means for discharging the reservoir contents through the cannula. The cannula 11 is fixed relative to the casing and projects b ...


2
Giorgio Cirelli, Hans Steffen, Christian Surber: Portable injection appliance. Hoffmann La Roche, Jon S Saxe, Bernard S Leon, A Kate Huffmann, December 12, 1989: US04886499 (464 worldwide citation)

The portable appliance is of use for the subcutaneous or intradermal injection of a liquid formulation of an active principle and it comprises in combination: a supply vessel for the formulation; an injection needle adapted to communicate with the vessel; pump means for emptying the vessel through t ...


3
David H Gelfand, Pamela M Holland, Randall K Saiki, Robert M Watson: Nucleic acid detection by the 5-3exonuclease activity of polymerases acting on adjacently hybridized oligonucleotides. Hoffmann La Roche, George M Gould, Dennis P Tramaloni, Stacey R Sias, January 30, 1996: US05487972 (271 worldwide citation)

A process of detecting a target nucleic acid using labeled oligonucleotides which uses the 5' to 3' nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and thus releasing labeled oligonucleotide fragments for detection. This process is e ...


4
Handa Balraj Krishan, Machin Peter James, Martin Joseph Armstrong, Redshaw Sally, Thomas Gareth John: Amino acid derivatives.. Hoffmann La Roche, December 20, 1989: EP0346847-A2 (262 worldwide citation)

Compounds of the formula wherein R represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, cycloalkylcarbonyl, aralkanoyl, aroyl, heterocyclylcarbonyl, alkylsulphonyl, arylsulphonyl, monoaralkylcarbamoyl, cinnamoyl or alpha -aralkoxycarbonylaminoalkanoyl and R represents hydrogen or R and R together ...


5
Klein Bernard: Methods and compositions for determining glucose in blood. Hoffmann La Roche, April 4, 1972: US3653841 (246 worldwide citation)

Colorimetric methods and compositions for quantitatively determining the glucose content of blood plasma or serum by heating a deproteinized sample of blood plasma or serum with an alkaline ferricyanide solution, followed by the addition of ferric ions and a 5-(2-pyridyl)-2H-1,4-benzodiazepine or wa ...


6
Giorgio Cirelli, Benno Rothenhausler, Hans Steffen: Device for introducing active substance into a patient. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, December 15, 1998: US05848990 (213 worldwide citation)

A device for introducing an active substance solution into a patient and with means for fastening to the skin and a cannula. The cannula is held in a withdrawn position by a retaining and releasing mechanism before use and, after release, is propelled into the patient's skin. A connector connected t ...


7
Robert Karasiewicz, Carlo Nalin, Perry Rosen: Peg-interferon conjugates. Hoffmann La Roche, George M Gould, William H Epstein, Catherine R Roseman, January 17, 1995: US05382657 (204 worldwide citation)

Substituted PEG-interferon conjugates of formulae IA and IB where PEG is linked by means of activated linking reagents of formulae IIA, IIB, or IIB-1 to an amino group in the interferon, and activated linking reagents of formulae IIA, IIB, or IIB-1. The conjugates are not readily susceptible to in v ...


8
Peter Loeliger: Stilbene derivatives. Hoffmann La Roche, Jon S Saxe, George M Gould, William H Epstein, April 20, 1982: US04326055 (177 worldwide citation)

This invention is directed to 5,6,7,8-tetrahydro-naphthyl or indanyl stilbene derivatives which are useful as tumor inhibiting agents, in the treatment of neoplasms, dermatological conditions and rheumatic illnesses.


9
Kary B Mullis, Larry Johnson, Richard A Leath, Timothy J Wennberg, Louis M Mezei, Joseph T Widunas: Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps. Hoffmann La Roche, Davis Hoxie Faithfull & Hapgood, August 2, 1994: US05333675 (176 worldwide citation)

There is disclosed herein a machine for performing nucleic acid amplification under computer control. The machine utilizes any one of a number of heating and cooling systems under control of a host computer which directs the heating and cooling systems to heat and cool a reaction-chamber-containing ...


10
Higuchi Russell G, Watson Robert M: Monitoring multiple reactions simultaneously and analyzing same.. Hoffmann La Roche, March 1, 1995: EP0640828-A1 (176 worldwide citation)

An apparatus for monitoring multiple nucleic acid amplifications simultaneously. In order to provide real-time monitoring of the amplification product of multiple nucleic acid amplifications simultaneously the apparatus is characterized in that it comprises a thermal cycler (12) including a heat con ...