1
Hoffmann Erich, Jin Hong, Lu bin, Duke Gregory, Kemble George, Chen Zhongying: Multi plasmid system for the production of influenza virus. Medimmune Vaccines, Hoffmann Erich, Jin Hong, Lu bin, Duke Gregory, Kemble George, Chen Zhongying, ALBAN Patrick Scott, December 8, 2005: WO/2005/115448 (14 worldwide citation)

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing ...


2
Hoffmann Erich, Lipatov Aleksandr S, Webster Robert G, Webby Richard J, Govorkova Elena A: Modified influenza virus for monitoring and improving vaccine efficiency. St Jude Children S Research Hospital, Hoffmann Erich, Lipatov Aleksandr S, Webster Robert G, Webby Richard J, Govorkova Elena A, LUDWIG S Peter, February 15, 2007: WO/2007/019094 (4 worldwide citation)

The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by alt ...


3
Lehner August, Jakusch Helmut, Koch Volker, Ohlinger Manfred, Kohl Albert, Lenz Werner, Schneider Norbert, Heilmann Peter, Veitch Ronald John, Hoffmann Erich, Hübner Werner, Jachow Harald, Lehnert Rudi: (De) Magnetische aufzeichnungsträger, (En) Magnetic recording media. Emtec Magnetics, Lehner August, Jakusch Helmut, Koch Volker, Ohlinger Manfred, Kohl Albert, Lenz Werner, Schneider Norbert, Heilmann Peter, Veitch Ronald John, Hoffmann Erich, Hübner Werner, Jachow Harald, Lehnert Rudi, SCHWEIGER G, October 3, 1996: WO/1996/030900

(EN) Described are tape-type magnetic recording media (I) including a non-magnetic substrate (III), at least one film applied to the substrate and, in at least one of these films, an inorganic acicular pigment (II) suitable for use as a supporting pigment, the ratio of the mean length to the mean di ...


4
Hoffmann Erich: Dna transfection system for the generation of infectious influenza virus. St Jude Children S Research Hospital, Hoffmann Erich, FEHLNER Paul F, November 8, 2001: WO/2001/083794

The present invention is based on the development of a dual promoter system (preferably a RNA pol I -pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably viruses with a negative single st ...


5
Ilmer Andreas, Lenz Werner, Kress Ria, Heilmann Peter, Veitch Ronald, Jakusch Helmut, Hoffmann Erich: (De) Magnetischer aufzeichnungsträger mit hoher aufzeichnungsdichte, (En) Magnetic recording support with high recording density. Emtec Magnetics, Ilmer Andreas, Lenz Werner, Kress Ria, Heilmann Peter, Veitch Ronald, Jakusch Helmut, Hoffmann Erich, HONEIT Ute, March 9, 2000: WO/2000/013176

(EN) Digital recording procedures wherein the recording support is not exposed to an obliterating magnetic field before recording are known in recent times. Such recording supports must therefore have good rewrite capability. It has been found that said requirement is fulfilled by two-layered record ...


6
Krauss Scott L, Webby Richard J, Hoffmann Erich, Webster Robert G, Kumar Mahesh: Avian influenza viruses, vaccines, compositions, formulations, and methods. Wyeth, St Jude Children S Research Hospital, Krauss Scott L, Webby Richard J, Hoffmann Erich, Webster Robert G, Kumar Mahesh, COLLAZO Marie, November 1, 2007: WO/2007/124479

A vaccine composition and method which is effective in preventing or ameliorating Avian Influenza Virus infection is set forth herein. The vaccine contains at least two inactivated strains of avian influenza virus, wherein the combined hemagglutinin (HA) total is at least about 200 HA/dose of the va ...