1
David H Gelfand, Pamela M Holland, Randall K Saiki, Robert M Watson: Homogeneous assay system using the nuclease activity of a nucleic acid polymerase. Hoffman La Roche, George M Gould, Dennis P Tramaloni, Stacev R Sias, May 11, 1993: US05210015 (646 worldwide citation)

The present invention is directed to a process of detecting a target nucleic acid using labeled oligonucleotides. This process uses the 5' to 3' nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide frag ...


2
Henry A Erlich, Russell G Higuchi: Methods for nucleic acid amplification. Hoffman La Roche, George M Gould, Patricia S Rocha, Stacey R Sias, May 24, 1994: US05314809 (143 worldwide citation)

Methods are provided for enhanced specificity and sensitivity of nucleic acid amplification. The methods are simplified nested amplification procedures wherein both inner and outer primer pairs are present in the amplification reaction mixture. According to the methods, the thermocycling profile, as ...


3
David H Gelfand, Thomas W Myers: Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription. Hoffman La Roche, George M Gould, Dennis P Tramaloni, Stacey R Sias, May 10, 1994: US05310652 (136 worldwide citation)

Methods are provided for the replication and amplification of RNA sequences by thermoactive DNA polymerases. In a preferred embodiment, high temperature reverse transcription is coupled to nucleic acid amplification in a one tube, one enzyme procedure using a thermostable DNA polymerase. Methods for ...


4
John Hakimi, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffman La Roche, George W Johnston, William H Epstein, Lewis J Kreisler, November 10, 1998: US05834594 (120 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


5
Navnit Hargovindas Shah, Aruna M Railkar, Wantanee Phuapradit: Colon targeted delivery system. Hoffman La Roche, George W Johnston, William H Epstein, Briana C Buchholz, March 21, 2000: US06039975 (92 worldwide citation)

A novel delivery system for targeting drugs to the colon is herein described. The system is a tablet comprised of three parts: 1) an outer enteric coating, 2) an inner semi-permeable polymer membrane containing a plasticizer and 3) a central core comprising swelling excipients and an active ingredie ...


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John A McLane, Milan R Uskokovic: Method for inhibiting hyperproliferative diseases. Hoffman La Roche, George M Gould, George W Johnston, Alan P Kass, June 4, 1991: US05021451 (74 worldwide citation)

A method of treating hyperproliferative skin diseases, such as psoriasis, using a compound of formula ##STR1## wherein R.sub.1 is hydrogen when R.sub.2 is hydroxy, and R.sub.1 is methyl when R.sub.2 is hydrogen; and A is alkyl; cycloalkyl; alkenyl; alkyl substituted with trifluoromethyl; phenyl; hal ...


8
Manfred Brockhaus, Zlatko Dembic, Reiner Gentz, Werner Lesslauer, Hansruedi Lotscher, Ernst Jurgen Schlaeger: Human TNF receptor. Hoffman La Roche, George W Johnston, William H Epstein, John P Parise, March 11, 1997: US05610279 (64 worldwide citation)

The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions) ...


9
Edilio Maurizio Borroni, Gerda Huber Trottmann, Gavin John Kilpatrick, Roger David Norcross: Adenosine receptor ligands and their use in the treatment of disease. Hoffman La Roche, George W Johnston, Patricia S Rocha Tramaloni, Kimberly J Prior, July 1, 2003: US06586441 (58 worldwide citation)

The invention relates to cyclic heteroaromatic compounds, containing at least one nitrogen atom, and to their use in the manufacture of medicaments for the treatment of diseases, related to adenosine receptor modulators, such as Alzheimer's disease, Parkinson's disease, neuroprotection, sc ...


10
Navnit Hargovindas Shah, Max Zeller: Tetrahydrolipstatin containing compositions. Hoffman La Roche, George W Johnston, William H Epstein, John P Parise, December 21, 1999: US06004996 (56 worldwide citation)

Product containing tetrahydrolipstatin as the active ingredient and pharmaceutically acceptable excipients, characterized in that it is in the form of particles with a diameter of 0.25 to 2 mm; and pharmaceutical preparation s or compositions for oral administration containing the product.