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Strupczewski Joseph T, Helsley Grover C, Chiang Yulin, Bordeau Kenneth J: (aryloxyalkyl)Heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, December 19, 1990: EP0402644-A1 (106 worldwide citation)

This invention related to compounds of the formula: wherein X is -O-, -S-, - @H, or -@-R; p is 1 or 2; Y is hydrogen, C1 to C6 alkyl, -OH, Cl, F, Br, I, C1 to C6 alkoxy, -CF3, NO2, or -NH2, when p is 1; Y is C1 to C6 alkoxy when p is 2 and X is -O-; R is selected from the group consisting of lower a ...


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Strupczewski Joseph T: 3-(piperidinyl)- and 3-(pyrrolidinyl)-1h-indazoles, a process for their preparation and their use as a medicament.. Hoechst Roussel Pharma, April 3, 1985: EP0135781-A1 (103 worldwide citation)

Novel 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles, intermediates and processes for the preperation thereof, and their use for treating psychoses and alleviating pain are disclosed.


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Strupczewski Joseph Thomas: 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments.. Hoechst Roussel Pharma, February 8, 1989: EP0302423-A2 (84 worldwide citation)

The present invention relates to novel 1-phenyl-3-(1-piperazinyl)-1H-indazoles and intermediates and a process for the preparation thereof. The compounds according to the invention exhibit analgesic, anti-convulsive and anti-depressant activities, and can therefore be used as medicaments.


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Hamer Russel Richard Lee, Helsley Grover Cleveland, Glamkowski Edward J, Chiang Yulin: 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indoles, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, January 20, 1988: EP0253372-A2 (34 worldwide citation)

There are described compounds of the formula where (a) X is O or S; (b) R is H, loweralkyl, where Y is O or S; R2 is loweralkyl, cycloalkyl, bicycloalkyl, cycloalkenyl, aryl, arylloweralkyl, heteroaryl or heteroarylloweralkyl, R3 is H or lower alkyl or the group -NR2R3 taken as a whole is 1-pyrrolid ...


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Shutske Gregory M, Pierrat Frank A: 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, April 30, 1986: EP0179383-A2 (34 worldwide citation)

There are disclosed compounds having the formula for wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR2 where R2 is loweralkyl, or NR3R4 where R3 and R4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R1 is hydrogen ...


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Strupczewski Joseph T, Helsley Grover C, Chiang Yulin, Bordeau Kenneth J, Glamkowski Edward J: Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics.. Hoechst Roussel Pharma, May 19, 1993: EP0542136-A1 (32 worldwide citation)

Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by ...


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Effland Richard Charles, Klein Joseph Thomas: N-(pyridinyl)-1h-indol-1-amines, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, October 26, 1988: EP0287982-A2 (28 worldwide citation)

There are disclosed compounds of the formula where m is 1 or 2; n is 1 or 2; P is 0 or 1; each R is independently hydrogen, halogen, loweralkyl, loweralkoxy, hydroxy, nitro, amino, loweralkylamino, loweralkylcarbonylamino, cyano, formyl, loweralkoxycarbonyl, loweralkylthio or loweralkoxycarbonyllowe ...


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Kosley Raymond W Jr, Cherill Robert J: Labdan-derivatives, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, September 3, 1986: EP0193132-A2 (27 worldwide citation)

The present invention relates to novel labdanes, intermediates and processes for the preparation thereof. The compounds have the ability to reduce elevated intraocular pressure and can, therefore, be used as medicaments.


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Effland Richard Charles, Klein Joseph Thomas: Alpha-alkyl-4-amino-3-quinoline-methanols and 1-(4-aralkylamino-3-quinolinyl) alkanones, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, March 9, 1988: EP0258755-A1 (26 worldwide citation)

There are described compounds of the formula where X is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl; R is - @-R4 or -@@-R4, R4 being loweralkyl; R1 is hydrogen, loweralkyl or arylloweralkyl; R2 is hydrogen, loweralkyl or arylloweralkyl; and R3 is loweralkyl, with the proviso that w ...