1
Gustavson Mark, Giltnane Jennifer, Dolled Filhart Marisa P, Camp Robert L, Rimm David L: Use of subcellular localization profiles as prognostic or predictive indicators. Yale University, Historx, Gustavson Mark, Giltnane Jennifer, Dolled Filhart Marisa P, Camp Robert L, Rimm David L, ARNOLD Beth E, November 15, 2007: WO/2007/130677 (21 worldwide citation)

The method of the invention pertains to determining the signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transd ...


2
David L Rimm, Gregory Tedeschi, Robert L Camp, Mark Gustavson: Methods for making cancer prognoses based on subcellular localization of biomarkers. Yale University, Historx, Cooper & Dunham, John P White, May 4, 2010: US07709222 (13 worldwide citation)

This invention provides a method of making a prognosis for a patient afflicted with a type of cancer such as colon cancer, based upon quantification of biomarkers such as thymidylate synthase in subcellular compartments.


3
Jason Christiansen, Dylan M Reilly, Brian Bourke Martin, Mark Gustavson: Automatic exposure time selection for imaging tissue. HistoRx, Gilberto M Villacorta, Nikhil S Palekar, Foley & Lardner, July 12, 2011: US07978258 (9 worldwide citation)

The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is compos ...


4
Jason Christiansen, Robert Pinard, Maciej P Zerkowski, Gregory R Tedeschi: Method and system for standardizing microscope instruments. HistoRx, Gilberto M Villacorta, Foley & Lardner, March 15, 2011: US07907271 (7 worldwide citation)

Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be u ...


5
Robert Pinard, Gregory R Tedeschi, Christine Williams, Dongxiao Wang: Methods and system for validating sample images for quantitative immunoassays. HistoRx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, April 17, 2012: US08160348 (5 worldwide citation)

A method and system for automatically evaluating quality of a slide-mounted tissue sample includes receiving a digital image of a magnified portion of the slide-mounted tissue sample. At least one quantitative quality indicator is automatically determined for at least one of the samples, and the dig ...


6
Jason H Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Dylan M Reilly, Gregory R Tedeschi: Compartment segregation by pixel characterization using image data clustering. Historx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, December 18, 2012: US08335360 (4 worldwide citation)

The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator ...


7
Christiansen Jason, Pinard Robert, Zerkowski Maciej P, Tedeschi Gregory R: Method and system for standardizing microscope instruments. Historx, Christiansen Jason, Pinard Robert, Zerkowski Maciej P, Tedeschi Gregory R, VILLACORTA Gilberto M, December 24, 2008: WO/2008/156669 (4 worldwide citation)

Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be u ...


8
Reilly Dylan M, Bourke Martin Brian, Gustavson Mark, Christiansen Jason: Automatic exposure time selection for imaging tissue. Historx, Reilly Dylan M, Bourke Martin Brian, Gustavson Mark, Christiansen Jason, VILLACORTA Gilberto M, March 5, 2009: WO/2009/029810 (4 worldwide citation)

The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is compos ...


9
Pinard Robert, Tedeschi Gregory R, Gustavson Mark: Method and system for determining an optimal dilution of a reagent. Historx, Pinard Robert, Tedeschi Gregory R, Gustavson Mark, VILLACORTA Gilberto M, February 12, 2009: WO/2009/020621 (3 worldwide citation)

A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment of the claimed method, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective pl ...


10
Pinard Robert, Tedeschi Gregory R, Williams Christine, Wang Donaxiao: Methods and system for validating sample images for quantitative immunoassays. Historx, Pinard Robert, Tedeschi Gregory R, Williams Christine, Wang Donaxiao, VILLACORTA Gilberto M, February 12, 2009: WO/2009/020972 (3 worldwide citation)

A method and system for automatically evaluating quality of a slide -mounted tissue sample includes receiving a digital image of a magnified portion of the slide- mounted tissue sample. At least one quantitative quality indicator is automatically determined for at least one of the samples, and the d ...