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Greferath Ruth, Hickman David, Muhs Andreas, Pfeifer Andrea, Nicolau Claude: A beta 1-42 specific monoclonal antibodies with therapeutic properties. Ac Immune, Greferath Ruth, Hickman David, Muhs Andreas, Pfeifer Andrea, Nicolau Claude, VOSSIUS Siebertstrasse 4 81675 Munich, June 21, 2007: WO/2007/068412 (34 worldwide citation)

The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid ...


2
Nicolau Yves Claude, Greferath Ruth, Hickman David: Methods and compositions comprising supramolecular constructs. Ac Immune, Nicolau Yves Claude, Greferath Ruth, Hickman David, PRATT John S, September 9, 2005: WO/2005/081872 (23 worldwide citation)

The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion pro ...


3
Tosi P F, Madoulet Claudine, Nicolau Claude, Hickman David T: (Fr) Vaccin therapeutique cible contre la p-glycoproteine 170 pour inhiber la resistance multidrogues dans le traitement des cancers, (En) Targeted therapeutic vaccine against p-glycoprotein 170 for inhibiting multi-drug resistance in the treatment of cancers. Ac Immune, Tosi P F, Madoulet Claudine, Nicolau Claude, Universite de Reims, Hickman David T, MEIER Jürgen, February 17, 2005: WO/2005/014036 (2 worldwide citation)

(EN) The object of the invention is an immunogenic composition characterized in that it comprises a vehicle and conjugates as an antigenic structure,said conjugates fully or partially comprising amino acid sequences of at least one peptide derived from an extracellular loop of protein P-170. Each pe ...


4
REIS Pedro, HICKMAN David, PIHLGREN BOSCH Maria, MUHS Andreas, PFEIFER Andrea: PRÉPARATION DUN PRODUIT DE RECOMBINAISON ANTIGÉNIQUE, LIPOSOME-BASED CONSTRUCT COMPRISING A PEPTIDE MODIFIED THROUGH HYDROPHOBIC MOIETIES. AC IMMUNE, REIS Pedro, HICKMAN David, PIHLGREN BOSCH Maria, MUHS Andreas, PFEIFER Andrea, BASTIAN Werner, May 3, 2012: WO/2012/055933

The present invention relates to method for preparing liposome-based constructs comprising a peptide, particularly an antigenic peptide, of interest modified through hydrophobic moieties reconstituted in liposomes and to the antigenic constructs obtained with said method. The invention further relat ...


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HICKMAN David, LÓPEZ DEBER María Pilar, MUHS Andreas: Vaccin obtenu par génie génétique, Vaccine engineering. Ac Immune, HICKMAN David, LÓPEZ DEBER María Pilar, MUHS Andreas, Werner Bastian, February 16, 2012: WO/2012/020124

The method and constructs disclosed and claimed herein allow to control peptide conformation by modulation of the peptide lipidation pattern, spacer and liposome composition, or via co-administration with small molecules. Accordingly, this technology can be applied to the rational design of liposoma ...