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Van, Acker Koenraad Lodewijk August, Bunkens Lieve Elisabeth Louis, Dams Géry Karel Julia, Hertogs Kurt, Ivens Tania Pauline Eduard, Nijs Erik Jos Amandus: Time-of-addition assay for identifying anti-viral compounds. Tibotec Pharmaceuticals, Van, Acker Koenraad Lodewijk August, Bunkens Lieve Elisabeth Louis, Dams Géry Karel Julia, Hertogs Kurt, Ivens Tania Pauline Eduard, Nijs Erik Jos Amandus, DAELEMANS Frank, March 31, 2005: WO/2005/028669 (4 worldwide citation)

The present invention relates to a multi-well assay for identifying a compound inhibiting the replication cycle of a micro-organism, for example, HIV, and to an apparatus for carrying out an assay according to the present invention. The invention further relates to compounds identifiable with an ass ...


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Simmen Kenneth Alan, Van, Acker Koenraad Lodewijk August, Wigerinck Piet Tom Bert Paul, Surleraux Dominique Louis Nestor Ghislain, Dams Géry Karel Julia, Quirynen Ludo Maria Marcel, Hertogs Kurt, Pauwels Rudi Wilfried Jan: Hcv inhibitiing sulfonamides. Tibotec Pharmaceuticals, Simmen Kenneth Alan, Van, Acker Koenraad Lodewijk August, Wigerinck Piet Tom Bert Paul, Surleraux Dominique Louis Nestor Ghislain, Dams Géry Karel Julia, Quirynen Ludo Maria Marcel, Hertogs Kurt, Pauwels Rudi Wilfried Jan, DAELEMANS Frank, April 7, 2005: WO/2005/030194 (2 worldwide citation)

The present invention concerns sulfonamide derivatives having the general formula (I) and N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs and esters thereof, wherein Q1 is -S- or -O-; R1 is hydrogen, C1-6alkyl, hydroxy, amino, halogen, aminoC1-4alkyl and mono-or di(C1-4 alkyl)amino ...


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Hertogs Kurt, Larder Brendan, Pauwels Rudi Wilfried Jan: New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance. Virco, Hertogs Kurt, Larder Brendan, Pauwels Rudi Wilfried Jan, DAELEMANS Frank, December 7, 2000: WO/2000/073511

The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target populati ...


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Hertogs Kurt, Larder Brendan, Harrigan Richard P: Establishment of biological cut-off values for predicting resistance to therapy. Virco Bvba, Hertogs Kurt, Larder Brendan, Harrigan Richard P, DAELEMANS Frank, April 25, 2002: WO/2002/033402

The present invention concerns methods and systems for improving the accuracy of predicting resistance of a disease to a therapy. In one embodiment of the invention, mean and standard deviation (SD) values of fold change in normalized sensitivity, relative to a laboratory wild type standard pathogen ...


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Dehertogh Pascale Alfons Rosa, Hertogs Kurt, Larder Brendan, Wang Dechao: Mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance. Virco Bvba, Dehertogh Pascale Alfons Rosa, Hertogs Kurt, Larder Brendan, Wang Dechao, DAELEMANS Frank, April 25, 2002: WO/2002/033638

The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target populati ...


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De, Bethune Marie Pierre Tmmg, de, Meyer Sandra, Hertogs Kurt, Lu Rong Jian, Michiels Lieve Emma Jan, Tahri Abdellah, Xie Dong, Eissenstat Michael: Small molecule entry inhibitors. Tibotec Pharmaceuticals, de, Bethune Marie Pierre, Tmmg, de, Meyer Sandra, Hertogs Kurt, Lu Rong Jian, Michiels Lieve Emma Jan, Tahri Abdellah, Xie Dong, Eissenstat Michael, DAELEMANS Frank, September 18, 2003: WO/2003/075907

The present invention concerns a compound having the formula (I) a N-oxide form, a stereochemical isomer, racemic mixture, salt prodrug, ester or metabolite thereof. It further relates to processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic k ...