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Dey Kaka, Gao Donghong Amy, Goldberg Daniel R, Heim Riether Alexander, Mangette John E, Mugge Ingo Andreas, Snow Roger, Swinamer Alan David, Wu Jiang Ping, Xiong Zhaoming, Yang Yu: Ccr10 antagonists. Boehringer Ingelheim International, Boehringer Ingelheim Pharma & Co Kg, Dey Kaka, Gao Donghong Amy, Goldberg Daniel R, Heim Riether Alexander, Mangette John E, Mugge Ingo Andreas, Snow Roger, Swinamer Alan David, Wu Jiang Ping, Xiong Zhaoming, Yang Yu, MORRIS Michael P, April 23, 2009: WO/2009/052078 (21 worldwide citation)

The invention relates to a compound of formula (I) or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The invention also relates to methods of using the compounds of formula (I) and compositions thereof to treat various di ...


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Heim Riether Alexander, Rotella David Paul: Methods for synthesizing imidazotriazinones. Lexicon Genetics Incorporated, Heim Riether Alexander, Rotella David Paul, ISHIMOTO Lance K, November 30, 2006: WO/2006/127368

Methods of synthesizing imidazotriazinones, such as vardenafil, and compositions useful for the same are disclosed.


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HEIM RIETHER Alexander, LIANG Shuang, PADYANA Anil Kumar, TAYLOR Steven John, ZHANG Qiang: ÉTHERS DARYLPYRAZOLE EN TANT QUINHIBITEURS DE LEUCOTRIÈNE A4 HYDROLASE, ARYLPYRAZOLE ETHERS AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE. BOEHRINGER INGELHEIM INTERNATIONAL, HEIM RIETHER Alexander, LIANG Shuang, PADYANA Anil Kumar, TAYLOR Steven John, ZHANG Qiang, MORRIS Michael P, January 24, 2013: WO/2013/012844

The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein A1, A2, A3, L1, L2 and D are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present in ...