1
Thomas P Hedman, John P Kostuik, Geoffrey R Fernie, Brian E Maki: Artificial spinal disc. Health & Research Services, Rogers Bereskin & Parr, July 26, 1988: US04759769 (827 worldwide citation)

An artificial disc for a human spine. The disc has upper and lower members hinged together at their rear portions and biased apart at their fronts by stiff coil springs. Rear stop surfaces limit the opening movement of the members. Vertically projecting tabs at the front and side of each member are ...


2
Sanjay Tyagi, Fred R Kramer, Paul M Lizardi: Detectably labeled dual conformation oligonucleotide probes, assays and kits. The Public Health Research Institute of the City of New York, Fish & Richardson P C, July 20, 1999: US05925517 (524 worldwide citation)

Unimolecular and bimolecular hybridization probes for the detection of nucleic acid target sequences comprise a target complement sequence, an affinity pair holding the probe in a closed conformation in the absence of target sequence, and either a label pair that interacts when the probe is in the c ...


3
Heather L Davis, Joachim Schorr, Arthur M Krieg: Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant. University of Iowa Research Foundation, Coley Pharmaceutical, Ottawa Health Research Institute, Wolf Greenfield & Sacks P C, June 18, 2002: US06406705 (291 worldwide citation)

The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be ...


4
Sanjay Tyagi, Fred Russell Kramer: Nucleic acid detection probes having non-FRET fluorescence quenching and kits and assays including such probes. The Public Health Research Institute of the City of New York, Fish & Richardson PC, November 21, 2000: US06150097 (265 worldwide citation)

Nucleic acid hybridization probes having a first conformation when not interacting with a target and a second conformation when interacting with a target, and having the ability to bring a label pair into touching contact in one conformation but not the other, are labeled with a non-FRET pair of chr ...


5
Arthur M Krieg, Heather L Davis, Tong Wu, Joachim Schorr: Vectors and methods for immunization or therapeutic protocols. University of Iowa Research Foundation, Loeb Health Research Institute at the Ottawa Hospital, Coley Pharmaceutical, Wolf Greenfield & Sacks P C, January 15, 2002: US06339068 (230 worldwide citation)

The present invention shows that DNA vaccine vectors can be improved by removal of CpG-N motifs and optional addition of CpG-S motifs. In addition, for high and long-lasting levels of expression, the optimized vector should include a promoter/enhancer that is not down-regulated by the cytokines indu ...


6
Paul M Lizardi, Fred R Kramer, Sanjay Tyagi, Cesar E Guerra, Hilda M L Buyoli: Nucleic acid process containing improved molecular switch. The Public Health Research Institute, The Salk Instiute for Biological Studies, Davis Hoxie Faithfull and Hapgood, June 2, 1992: US05118801 (223 worldwide citation)

A probe for the detection of a nucleic acid target sequence containing a molecular switch comprising three essential elements: a probe sequence of 20-60 nucleotides surrounded by switch sequences of 10-40 nucleotides which are complementary to each other, wherein the state of the switch is useful fo ...


7
Enzo Paoletti, Dennis Panicali: Modified vaccinia virus. Health Research Incorporated, Curtis Morris & Safford, July 29, 1986: US04603112 (215 worldwide citation)

What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms ...


8
Enzo Paoletti, Dennis Panicali: Modified vaccinia virus and methods for making and using the same. Health Research Incorporated, Curtis Morris & Safford, September 6, 1988: US04769330 (185 worldwide citation)

What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms ...


9
Enzo Paoletti, Dennis Panicali: Method for immunizing animals with synthetically modified vaccinia virus. Health Research Incorporated, Curtis Morris & Safford, February 2, 1988: US04722848 (172 worldwide citation)

What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms ...


10
Thomas J Dougherty, William R Potter, Kenneth R Weishaupt: Drugs comprising porphyrins. Health Research, Vincent L Carney, March 10, 1987: US04649151 (166 worldwide citation)

To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulf ...