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Brown Matthew Lee, Cheung Mui, Dickerson Scott Howard, Gauthier Cassandra, Harris Philip Anthony, Hunter Robert Neil Iii, Pacofsky Gregory, Peel Michael Robert, Stafford Jeffrey Alan: Chemical compounds. Smithkline Beecham Corporation, Brown Matthew Lee, Cheung Mui, Dickerson Scott Howard, Gauthier Cassandra, Harris Philip Anthony, Hunter Robert Neil Iii, Pacofsky Gregory, Peel Michael Robert, Stafford Jeffrey Alan, LEVY David J, April 22, 2004: WO/2004/032882 (14 worldwide citation)

Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.


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Cheung Mui, Harris Philip Anthony, Hasegawa Masaichi, Ida Satoru, Kano Kazuya, Nishigaki Naohiko, Sato Hideyuki, Veal James Marvin, Washio Yoshiaki, West Rob I: Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors. Glaxo Group, Cheung Mui, Harris Philip Anthony, Hasegawa Masaichi, Ida Satoru, Kano Kazuya, Nishigaki Naohiko, Sato Hideyuki, Veal James Marvin, Washio Yoshiaki, West Rob I, LEVY David J, June 6, 2002: WO/2002/044156 (3 worldwide citation)

Benzimidazole derivatives of Formula (I), which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.


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Harris Philip Anthony, Kuyper Lee Frederick, Lackey Karen Elizabeth, Veal James Marvin: Substituted aza-oxindole derivatives. Glaxo Group, Harris Philip Anthony, Kuyper Lee Frederick, Lackey Karen Elizabeth, Veal James Marvin, LEVY David J, September 21, 2000: WO/2000/055159 (1 worldwide citation)

Compounds of formula (I) and methods for their use and manufacture. The compounds and compositions of the present invention are generally useful pharmacologically as therapeutic agents in disease states alleviated by the inhibition or antagonism of protein kinase activated signalling pathways in gen ...


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Boloor Amogh, Cheung Mui, Davis Ronda, Harris Philip Anthony, Hinkle Kevin, Mook Robert Anthony Jr, Stafford Jeffery Alan, Veal James Marvin: Pyrimidineamines as angiogenesis modulators. Glaxo Group, Boloor Amogh, Cheung Mui, Davis Ronda, Harris Philip Anthony, Hinkle Kevin, Mook Robert Anthony Jr, Stafford Jeffery Alan, Veal James Marvin, LEVY David J, August 1, 2002: WO/2002/059110 (1 worldwide citation)

Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.


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Harris Philip Anthony, Wang Tony Yuhuan: Inhibitors of glycogen synthase kinase-3. Smithkline Beecham Corporation, Harris Philip Anthony, Wang Tony Yuhuan, LEVY David J, March 27, 2003: WO/2003/024447

The present invention relates generally to inhibitors of the serine/threoine kinase GSK3, and more particularly to triarylimidazole compounds of the following formula (I):


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Kuyper Lee Frederick, Lackey Karen Elizabeth, Wood Iii Edgar Raymond, Harris Philip Anthony, Hunter Robert N, Mcnutt Robert Walton Jr, Peel Michael Robert: Oxindole derivatives. Glaxo Group, Kuyper Lee Frederick, Lackey Karen Elizabeth, Wood Iii Edgar Raymond, Harris Philip Anthony, Hunter Robert N, Mcnutt Robert Walton Jr, Peel Michael Robert, LEVY David J, March 14, 2002: WO/2002/020513

The present invention is related to oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in ...


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