1
Gene Parunak: Methods and systems for fluid control in microfluidic devices. Handylab, Pennie & Edmonds, June 10, 2003: US06575188 (139 worldwide citation)

The present invention relates to a valve for use in a microfluidic system. The valve includes a substrate defining an upstream channel and a downstream channel joined by a passage, wherein the passage comprises a first opposed wall disposed at an angle to a central axis of the upstream channel. A th ...


2
Kalyan Handique, Karthik Ganesan, Sundaresh N Brahmasandra: Methods and systems for control of microfluidic devices. HandyLab, Fish & Richardson P C, March 7, 2006: US07010391 (127 worldwide citation)

The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion wh ...


3
Betty Wu, Karthik Ganesan, Kalyan Handique, Gene Parunak: Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids. HandyLab, Fish & Richardson P C, March 20, 2007: US07192557 (115 worldwide citation)

The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a lysing zone to receive the cell-containing sample and a positioning element to position the cell-containing sample in a lysing position in the vicinity of a lysing mechanism. The lys ...


4
Gene Parunak, Kalyan Handique, Betty Wu, Aaron Kehrer: Methods and systems for processing microfluidic samples of particle containing fluids. HandyLab, Fish & Richardson P C, September 18, 2007: US07270786 (109 worldwide citation)

The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a microfabricated substrate having an enrichment channel to prepare an enriched cell sample from the cell-containing liquid. A flow through member is in liquid communication with the e ...


5
Kalyan Handique: Heat-reduction methods and systems related to microfluidic devices. HandyLab, Pennie & Edmonds, February 17, 2004: US06692700 (107 worldwide citation)

A system and method for preventing or reducing unwanted heat in a microfluidic of the device while generating heat in selected regions of the device.


6
Karthik Ganesan: Microfluidic devices having a reduced number of input and output connections. Handylab, Fish & Richardson P C, February 8, 2005: US06852287 (106 worldwide citation)

A system and method for reducing the number of input/output connections required to connect a microfluidic substrate to an external controller for controlling the substrate. In one example, a microfluidic processing device is fabricated on a substrate having a plurality of N independently controllab ...


7
Jeff Williams, Kalyan Handique, Kerry Wilson: Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples. HandyLab, Knobbe Martens Olson & Bear, March 13, 2012: US08133671 (105 worldwide citation)

The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfl ...


8
Kalyan Handique, Gene Parunak: Moving microdroplets in a microfluidic device. HandyLab, Fish & Richardson P C, January 29, 2008: US07323140 (84 worldwide citation)

The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms a fluid network through which flui ...


9
Kalyan Handique, Sundaresh N Brahmasandra, Karthik Ganesan, Jeff Williams: Microfluidic system for amplifying and detecting polynucleotides in parallel. HandyLab, Knobbe Martens Olson & Bear, August 16, 2011: US07998708 (74 worldwide citation)

The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. ...


10
Kalyan Handique: Heat-reduction methods and systems related to microfluidic devices. HandyLab, Fish & Richardson P C, February 19, 2008: US07332130 (73 worldwide citation)

A system and method for preventing or reducing unwanted heat in a microfluidic of the device while generating heat in selected regions of the device. In one example, current is supplied to a heating element through electric leads, wherein the leads are designed so that the current density in the lea ...