1
Halland Nis, Nazare M, Lindenschmidt Andreas, Rkyek Omar, Urmann Matthias, Alonso Jorge: A transition metal catalyzed synthesis of n-aminoindoles. Sanofi Aventis, Halland Nis, Nazare M, Lindenschmidt Andreas, Rkyek Omar, Urmann Matthias, Alonso Jorge, THEN Johann, October 23, 2008: WO/2008/125207 (46 worldwide citation)

The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R0; R1; R2; R3; R4; R5; R6; A1; A2; A3; A4, Q, T and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide ...


2
Alonso Jorge, Lindenschmidt Andreas, Nazare Marc, R Kyen Omar, Urmann Mathias, Halland Nis: A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles. Sanofi Aventis, Alonso Jorge, Lindenschmidt Andreas, Nazare Marc, R Kyen Omar, Urmann Mathias, Halland Nis, THEN Johann, December 31, 2008: WO/2009/000412 (38 worldwide citation)

A regioselective metal catalyzed synthesis of benzimidazoles and azabenzimidazoles The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present inventio ...


3
Alonso Jorge, Lindenschmidt Andreas, Nazaré Marc, Halland Nis, Rkyek Omar, Urmann Matthias: A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles. Sanofi Aventis, Alonso Jorge, Lindenschmidt Andreas, Nazaré Marc, Halland Nis, Rkyek Omar, Urmann Matthias, THEN Johann, January 24, 2008: WO/2008/009348 (12 worldwide citation)

The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein RO; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wid ...


4
Alonso Jorge, Lindenschmidt Andreas, Nazaré Marc, Urmann Matthias, Halland Nis, R Kyek Omar: A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles. Sanofi Aventis, Alonso Jorge, Lindenschmidt Andreas, Nazaré Marc, Urmann Matthias, Halland Nis, R Kyek Omar, THEN Johann, December 31, 2008: WO/2009/000413 (9 worldwide citation)

The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4; Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide va ...


5
Kallus Christopher, Broenstrup Mark, Czechtizky Werngard, Evers Andreas, Follmann Markus, Halland Nis, Schreuder Herman: (De) Harnstoff- und sulfamidderivate als inhibitoren von tafia, (En) Urea and sulfamide derivatives as tafia inhibitors. Sanofi Aventis, Kallus Christopher, Broenstrup Mark, Czechtizky Werngard, Evers Andreas, Follmann Markus, Halland Nis, Schreuder Herman, THEN Johann, June 12, 2008: WO/2008/067909 (5 worldwide citation)

(EN) The invention relates to compounds of formula (I) which are inhibitors of activated thrombin-activatable fibrinolysis inhibitor. Said compounds of formula (I) are suitable for producing medicaments used for the prevention, secondary prevention, and treatment of one or several diseases associate ...


6
R Kyek Omar, Nazarè Marc, Lindenschmidt Andreas, Urmann Matthias, Halland Nis, Alonso Jorge: A process for the palladium-catalyzed coupling of terminal alkynes with aryl tosylates. Sanofi Aventis, R Kyek Omar, Nazarè Marc, Lindenschmidt Andreas, Urmann Matthias, Halland Nis, Alonso Jorge, THEN Johann, January 8, 2009: WO/2009/003589 (1 worldwide citation)

The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process for aryl tosylates ...


7
Halland Nis, Jørgensen Karl Anker, Marigo Mauro, Braunton Alan, Bachmann Stephan, Schlüter Doris: Catalytic asymmetric synthesis of optically active &agr;-halo-carbonyl compounds. Cheminova, Halland Nis, Jørgensen Karl Anker, Marigo Mauro, Braunton Alan, Bachmann Stephan, Schlüter Doris, RASMUSSEN Preben, September 1, 2005: WO/2005/080298

A process for the catalytic asymmetric synthesis of an optically active compound of the formula (la) or (lb): wherein R is an organic group; X is halogen; Rl and R2which may the same or different represents H, or an organic group or Rl and R2 may be bridged together forming part of a ring system; R ...


8
Halland Nis, Jørgensen Karl Anker, Hansen Tore: Catalytic asymmetric synthesis of optically active compounds. Cheminova, Halland Nis, Jørgensen Karl Anker, Hansen Tore, RASMUSSEN Preben, June 19, 2003: WO/2003/050105

A one step catalytic asymmetric process for the synthesis of an optically active compound of formula la or lb wherein R is selected from C¿1-7? alkyl, C¿1-7? haloalkyl, C¿1-7? alkoxy, C¿1-7? haloalkoxy, halogen and hydroxy; R¿3? is H or C¿1-4? alkyl; R4 is selected from H, C¿1-7? alkyl, C¿1-7? haloa ...


9
NAZARÉ Marc, HALLAND Nis, SCHMIDT Friedemann, WEISS Tilo, DIETZ Uwe, HOFMEISTER Armin: [fr] N-[4-(1H-PYRAZOLO[3,4-B]PYRAZIN-6-YL)-PHÉNYL-SULFONAMIDES ET LEURS UTILISATION COMME PRODUITS PHARMACEUTIQUES, [en] N-[4-(1H-PYRAZOLO[3,4-B]PYRAZIN-6-YL)-PHENYL]-SULFONAMIDES AND THEIR USE AS PHARMACEUTICALS. NAZARÉ Marc, HALLAND Nis, SCHMIDT Friedemann, WEISS Tilo, DIETZ Uwe, HOFMEISTER Armin, SANOFI, KUJATH Eckard, March 28, 2013: WO/2013/041119

[en] The present invention relates to N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]- sulfonamides of the formula I, wherein Ar, R1, R2 and n have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds which modulate protein kinase activit ...


10
Halland Nis, Nazaré Marc, Lindenschmidt Andreas, Alonso Jorge, R Kyek Omar, Urmann Matthias: A transition metal catalyzed synthesis of 2h-indazoles. Sanofi Aventis, Halland Nis, Nazaré Marc, Lindenschmidt Andreas, Alonso Jorge, R Kyek Omar, Urmann Matthias, THEN Johann, December 31, 2008: WO/2009/000411

The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4; Q and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety ...