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Beigelman Leonid, Seiwert Scott D, Blatt Lawrence M, Andrews Steven, Haas Julia: Compounds and methods for inhibiting hepatitis c viral replication. Intermune, Array Biopharma, Beigelman Leonid, Seiwert Scott D, Blatt Lawrence M, Andrews Steven, Haas Julia, MALLON Joseph J, April 19, 2007: WO/2007/044893 (56 worldwide citation)

Macrocyclic compounds having the structures described herein arc useful for inhibiting replication of the hepatitis C virus (HCV). In preferred embodiments, the compounds are active against both the NS3 protease and the NS3 helicase of HCV. Formulae (I), (II), (III), (IV) and (V).


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Inaba Takashi, Haas Julia, Shiozaki Makoto, Littman Nicole M, Yasue Katsutaka, Andrews Steven W, Sakai Atushi, Fryer Andrew M, Matsuo Takafumi, Laird Ellen R, Suma Akira, Shinozaki Yuichi, Hori Yoshikazu, Imai Hiroto, Negoro Tamotsu: Cyclopropane compounds and pharmaceutical use thereof. Japan Tobacco, Inaba Takashi, Haas Julia, Shiozaki Makoto, Littman Nicole M, Yasue Katsutaka, Andrews Steven W, Sakai Atushi, Fryer Andrew M, Matsuo Takafumi, Laird Ellen R, Suma Akira, Shinozaki Yuichi, Hori Yoshikazu, Imai Hiroto, Negoro Tamotsu, GARRETT Arthur S, June 30, 2005: WO/2005/058884 (26 worldwide citation)

The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is - (CH2) m-X- (CH2)n-A1 et ...


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Fryer Andrew M, Shiozaki Makoto, Littmann Nicole M, Inaba Takashi, Andrews Steven W, Yasue Katsutaka, Laird Ellen R, Yokota Masahiro, Haas Julia, Imai Hiroto, Maeda Katsuya, Shinozaki Yuichi, Hori Yoshikazu: N-substituted-n-sulfonylaminocyclopropane compounds and pharmaceutical use thereof. Japan Tobacco, Fryer Andrew M, Shiozaki Makoto, Littmann Nicole M, Inaba Takashi, Andrews Steven W, Yasue Katsutaka, Laird Ellen R, Yokota Masahiro, Haas Julia, Imai Hiroto, Maeda Katsuya, Shinozaki Yuichi, Hori Yoshikazu, GARRETT Arthur S, June 30, 2005: WO/2005/058808 (21 worldwide citation)

The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1) : wherein R ...


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Beigelman Leonid, Andrews Steven W, Condroski Kevin R, Gunawaradana Indrani, Haas Julia: Inhibitors of viral replication. Intermune, Beigelman Leonid, Andrews Steven W, Condroski Kevin R, Gunawaradana Indrani, Haas Julia, MALLON Joseph J, April 26, 2007: WO/2007/047146 (5 worldwide citation)

The embodiments provide compounds of the general Formulas I-IV, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver ...