1

2

3

4

5

6

7
Blake James, Gunawardana Indrani W, Le Huerou Yvan, Mohr Peter J, Wallace Eli M, Wang bin: Pyrrolopyridines as kinase inhibitors. Array Biopharma, Blake James, Gunawardana Indrani W, Le Huerou Yvan, Mohr Peter J, Wallace Eli M, Wang bin, HARRIS Robert J, July 16, 2009: WO/2009/089352 (1 worldwide citation)

Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated ...


8
Blake James, Gunawardana Indrani W, Le Huerou Yvan, Mohr Peter J, Wallace Eli M, Wang bin: Pyrazolopyridines as kinase inhibitors. Array Biopharma, Blake James, Gunawardana Indrani W, Le Huerou Yvan, Mohr Peter J, Wallace Eli M, Wang bin, HARRIS Robert J, July 16, 2009: WO/2009/089359 (1 worldwide citation)

Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pat ...


9
Boyd Steven A, Condroski Kevin R, Thomas Allen, Gonzales Stephen S, Gunawardana Indrani W, Le, Huerou Yvan, Romoff Rodd T, Sullivan Francis X: Thioalkeneamides as transketolase inhibitors. Array Biopharma, Boyd Steven A, Condroski Kevin R, Thomas Allen, Gonzales Stephen S, Gunawardana Indrani W, Le, Huerou Yvan, Romoff Rodd T, Sullivan Francis X, HALEY James F Jr, October 13, 2005: WO/2005/095344

The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The inventi ...


10
Boyd Steven A, Condroski Kevin R, de, Meese Jason, Gonzales Stephen S, Gunawardana Indrani W, Kaplan Tomas, Le, Huerou Yvan, Lyssikatos Joseph, Romoff Todd T, Sullivan Francis X, Thomas Allen: Thiazoliums as transketolase inhibitors. Array Biopharma, Boyd Steven A, Condroski Kevin R, de, Meese Jason, Gonzales Stephen S, Gunawardana Indrani W, Kaplan Tomas, Le, Huerou Yvan, Lyssikatos Joseph, Romoff Todd T, Sullivan Francis X, Thomas Allen, HALEY James F Jr, October 13, 2005: WO/2005/095391

The present invention provides N-3'-pyridylmethyl or N-2'-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R1, R2, R3, Y, R5-R9, Ra-Rd, n and X- are as defined herein. The present invention also provides pharmaceutical compositions comprising ...