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Greferath Ruth, Hickman David, Muhs Andreas, Pfeifer Andrea, Nicolau Claude: A beta 1-42 specific monoclonal antibodies with therapeutic properties. Ac Immune, Greferath Ruth, Hickman David, Muhs Andreas, Pfeifer Andrea, Nicolau Claude, VOSSIUS Siebertstrasse 4 81675 Munich, June 21, 2007: WO/2007/068412 (34 worldwide citation)

The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid ...


2
Nicolau Yves Claude, Greferath Ruth, Hickman David: Methods and compositions comprising supramolecular constructs. Ac Immune, Nicolau Yves Claude, Greferath Ruth, Hickman David, PRATT John S, September 9, 2005: WO/2005/081872 (23 worldwide citation)

The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion pro ...


3
Nicolau Claude, Lehn Jean Marie, Fylaktakidou Konstantina C, Greferath Ruth: Calcium salt of myo-inositol 1,6:2,3:4,5 tripyrophosphate as an allosteric effector of hemoglobin. Oxyplus, Nicolau Claude, Lehn Jean Marie, Fylaktakidou Konstantina C, Greferath Ruth, BROSMORE Shirley E, September 28, 2006: WO/2006/102060 (5 worldwide citation)

The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and method ...


4
Nicolau Claude, Greferath Ruth, Fylaktakidou Konstantina C, Lehn Jean Marie: Use of inositol-tripyrophosphate in treating tumors and diseases. Oxyplus, Nicolau Claude, Greferath Ruth, Fylaktakidou Konstantina C, Lehn Jean Marie, BROSMORE Shirley E, July 19, 2007: WO/2007/081315 (1 worldwide citation)

Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-trip ...


5
Nicolau Claude, Lehn Jean Marie, Greferath Ruth: Erythropoietin complementation or replacement. Oxyplus, Universite Louis Pasteur de Strasbourg, Nicolau Claude, Lehn Jean Marie, Greferath Ruth, KING Intellectual Property Dept Patents 34th Floor 1180 Peachtree Street NE Atlanta Georgia 30309 3521, November 6, 2008: WO/2008/134082 (1 worldwide citation)

The present invention provides methods and compositions to replace up to 90 % of erythropoietin use in the treatment of anemias and hypoxias. The method employs acid and salt forms of inositol-tripyrophosphate (ITPP) isomers to shift the P50 value of hemoglobin, thereby improving the rate and effici ...


6
Nicolau Yves Claude, Greferath Ruth: Monoclonal antibodies specific for beta-amyloid.. Diagenics International Corporation, Nicolau Yves Claude, Greferath Ruth, MALONE Janina A, May 15, 2003: WO/2003/039467

This invention provides methods and compositions for the detection, diagnosis and treatment of amyloid-associated diseases, in particular, diseases comprising deposition of amyloid assemblies, fibrils, filaments, tangles, or plaques. A preferred composition comprises monoclonal antibodies that speci ...


7
Nicolau Claude, Greferath Ruth, Fylaktakidou Konstantina C, Lehn Jean Marie: Use of inositol-tripyrophosphate in treating tumors and diseases. Oxyplus, Nicolau Claude, Greferath Ruth, Fylaktakidou Konstantina C, Lehn Jean Marie, KING Intellectual Property Dept 34th Floor 1180 Peachtree Street NE Atlanta GA 30309 3521, October 25, 2007: WO/2007/120484

Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-trip ...


8
Nicolau Claude, Lehn Jean Marie, Fylaktakidou Konstantina C, Greferath Ruth: Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin. Oxyplus, Nicolau Claude, Lehn Jean Marie, Fylaktakidou Konstantina C, Greferath Ruth, King & Spalding Et Al, December 3, 2009: WO/2009/145751

The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amo ...