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Bartholomäus Johannes, Kugelmann Heinrich, Langner Klaus Dieter: (De) Gegen missbrauch gesicherte darreichungsform, (En) Dosage form that is safeguarded from abuse. Grünenthal, Bartholomäus Johannes, Kugelmann Heinrich, Langner Klaus Dieter, KUTZENBERGER Helga, May 6, 2004: WO/2004/037259 (65 worldwide citation)

(EN) The invention relates to a dosage form that is safeguarded from abuse. In addition to one or more active substances that could be subject to abuse, said form comprises two or more of the following constituents (a)-(d): (a) at least one substance that irritates the nasal and/or pharyngeal region ...


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Arkenau Elisabeth, Bartholomäus Johannes: (De) Verfahren zur herstellung einer gegen missbrauch gesicherten, festen darreinchungsform, (En) Method for the production of an abuse-proof, solid form of administration. Grünenthal, Arkenau Elisabeth, Bartholomäus Johannes, KUTZENBERGER Helga, November 3, 2005: WO/2005/102286 (63 worldwide citation)

(EN) The invention relates to a method for producing an abuse-proof, solid form of administration containing at least one active substance that could potentially be abused and a binding agent having a breaking resistance of =500 N. According to said method, ultrasound and a force are applied to a mi ...


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Bartholomäus Johannes, Kugelmann Heinrich: (De) Gegen missbrauch gesicherte darreichungsform, (En) Dosage form that is safeguarded from abuse. Grünenthal, Bartholomäus Johannes, Kugelmann Heinrich, WOLFF Felix, February 24, 2005: WO/2005/016313 (42 worldwide citation)

(EN) The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse an ...


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Bartholomäus Johannes, Kugelmann Heinrich, Arkenau Maric Elisabeth: (De) Gegen missbrauch gesicherte, orale darreichtungsform, (En) Oral dosage form safeguarded against abuse. Grünenthal, Bartholomäus Johannes, Kugelmann Heinrich, Arkenau Maric Elisabeth, KUTZENBERGER Helga, January 12, 2006: WO/2006/002884 (40 worldwide citation)

(EN) The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled opioid release for a once daily administering. The invention is characterized in that the oral dosage form comprises at least one opioid with an abuse potential (A), at least one syntheti ...


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Bartholomäus Johannes, Kugelmann Heinrich: (De) Gegen missbrauch gesicherte darreichungsform, (En) Form of administration secured against misuse. Grünenthal, Bartholomäus Johannes, Kugelmann Heinrich, WOLFF Felix, February 24, 2005: WO/2005/016314 (40 worldwide citation)

(EN) The invention relates to a form of administration which is secured against misuse and which is thermoformed without extrusion, comprising at least one synthetic or natural polymer having a resistance to breaking of at least 500 N in addition to one or several active ingredients with a misuse po ...


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Bartholomäus Johannes, Kugelmann Heinrich: (De) Gegen missbrauch gesicherte, orale darreichungsform enthaltend (1r, 2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol, (En) Oral dosage form safeguarded against abuse containing (1r, 2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol. Grünenthal, Bartholomäus Johannes, Kugelmann Heinrich, KUTZENBERGER Helga, January 12, 2006: WO/2006/002886 (37 worldwide citation)

(EN) The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled release of (1R, 2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol for a once daily administering. The invention is characterized in that the oral dosage form comprises the active ing ...


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Arkenau Elisabeth, Bartholomäus Johannes: (De) Verfahren zur herstellung einer gegen missbrauch gesicherten, festen darreichungsform unter verwendung eines planetwalzenextruders, (En) Method for producing a solid dosage form, which is safeguarded against abuse, while using a planetary gear extruder. Grünenthal, Arkenau Elisabeth, Bartholomäus Johannes, KUTZENBERGER Helga, January 12, 2006: WO/2006/002883 (34 worldwide citation)

(EN) The invention relates to a method for producing a solid dosage form, which is safeguarded against abuse, contains at least one active ingredient that has an abuse potential, and contains a synthetic and/or natural polymer with a breaking resistance of at least 500 N. The invention is characteri ...


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Bartholomäus Johannes, Arkenau Maric Elisabeth: (De) Verfahren zur herstellung einer gegen missbrauch gesicherten darreichungsform, (En) Method for the production of an administration form which is secured against misuse. Grünenthal, Bartholomäus Johannes, Arkenau Maric Elisabeth, KUTZENBERGER Helga, July 14, 2005: WO/2005/063214 (33 worldwide citation)

(EN) The invention relates to a method for the production of thermoformed administration forms, which are secured against misuse, containing at least one synthetic or natural polymer with a breaking resistance of at least 500 N, in addition to one or several active substances having a misuse potenti ...