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Cardozo Mario G, Cogan Derek, Cywin Charles Lawrence, Dahmann Georg, Disalvo Darren, Ginn John David, Prokopowicz Anthony S, Spero Denice M, Young Erick Richard Roush: 2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta. Boehringer Ingelheim Pharmaceuticals, Boehringer Ingelheim Pharma & Co Kg, Cardozo Mario G, Cogan Derek, Cywin Charles Lawrence, Dahmann Georg, Disalvo Darren, Ginn John David, Prokopowicz Anthony S, Spero Denice M, Young Erick Richard Roush, RAYMOND Robert P, August 12, 2004: WO/2004/067516 (34 worldwide citation)

Disclosed are novel compounds of formula (I) wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorde ...


2
Bosanac Todd, Ginn John David, Hickey Eugene Richard, Kirrane Thomas Martin, Liu Weimin, Prokopowicz Anthony S, Shih Cheng Kon, Snow Roger John, Turner Michael Robert, Wu Frank, Young Erick Richard, Schlyer Sabine K: Rho kinase inhibitors. Boehringer Ingelheim International, Boehringer Ingelheim Pharma & Co Kg, Bosanac Todd, Ginn John David, Hickey Eugene Richard, Kirrane Thomas Martin, Liu Weimin, Prokopowicz Anthony S, Shih Cheng Kon, Snow Roger John, Turner Michael Robert, Wu Frank, Young Erick Richard, Schlyer Sabine K, MORRIS Michael P, March 27, 2008: WO/2008/036540 (21 worldwide citation)

Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compos ...


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GINN John David, MARSHALL Daniel Richard, SIBLEY Robert, SORCEK Ronald John, YOUNG Erick Richard Roush, ZHANG Yunlong: Inhibiteurs de la rho kinase, Rho kinase inhibitors. Boehringer Ingelheim International, GINN John David, MARSHALL Daniel Richard, SIBLEY Robert, SORCEK Ronald John, YOUNG Erick Richard Roush, ZHANG Yunlong, MORRIS Michael P, January 12, 2012: WO/2012/006202 (1 worldwide citation)

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of Rho Kinase-medi ...


5
BERRY Angela, BOSANAC Todd, GINN John David, HOPKINS Tamara Denise, SCHLYER Sabine, SOLEYMANZADEH Fariba, WESTBROOK John, YU Maolin, ZHANG Zhonghua: [fr] ACTIVATEURS DE GUANYLATE CYCLASE SOLUBLE, [en] SOLUBLE GUANYLATE CYCLASE ACTIVATORS. BERRY Angela, BOSANAC Todd, GINN John David, HOPKINS Tamara Denise, SCHLYER Sabine, SOLEYMANZADEH Fariba, WESTBROOK John, YU Maolin, ZHANG Zhonghua, BOEHRINGER INGELHEIM INTERNATIONAL, MORRIS Michael P, February 21, 2013: WO/2013/025425

[en] The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R1 - R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of vario ...


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Ginn John David, Sorcek Ronald John, Turner Michael Robert, Young Erick Richard Roush: Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide compounds, their preparation and use. Boehringer Ingelheim International, Boehringer Ingelheim Pharma & Co Kg, Ginn John David, Sorcek Ronald John, Turner Michael Robert, Young Erick Richard Roush, MORRIS Michael P, December 21, 2007: WO/2007/146602

Disclosed are compounds of formula (I): (I) wherein R1 and R4 are defined herein, which are useful as inhibitors of the kinase activity of the IϰB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory dise ...