1
Brian Froehler, Robert J Jones: Oligonucleotides containing 5-propynyl pyrimidines. Gilead Sciences, Daryl D Muenchau, January 16, 1996: US05484908 (353 worldwide citation)

Oligonucleotides with enhanced hybridization binding possessing 5-propynyluracil and/or 5-propynylcytosine in place of uracil and cytosine, respectively. These oligonucleotides are useful in traditional hybridization assays for detection of a specific DNA sequence.


2
Mark Matteucci: Oligonucleotide analogs with novel linkages. Gilead Sciences, Morrison & Foerster, November 23, 1993: US05264564 (338 worldwide citation)

Oligonucleotide analogs wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by an formacetal/ketal type linkage are resistant to nucleases and do not need to exhibit the diastereomerism characteristic of many other oligonucleotide analogs, and thus are capable of st ...


3
Chris A Buhr, Mark Matteucci: 2modified nucleoside and nucleotide compounds. Gilead Sciences, Morrison & Foerster, November 14, 1995: US05466786 (335 worldwide citation)

Oligomers which have substituents on the 2' position are resistant to oligonucleases and furthermore can be derivatized to deliver reagents or drugs, to carry label, or to provide other properties.


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Brian Froehler, Mark Matteucci: Enhanced triple-helix and double-helix formation with oligomers containing modified purines. Gilead Sciences, Daryl D Muenchau, January 14, 1997: US05594121 (311 worldwide citation)

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain 7-deaza-7-substituted purines or related analogs. The oligomers of the invention are capable of (i) forming triple ...


6
Brian Froehler, Rick Wagner, Mark Matteucci, Robert J Jones, Arnold J Gutierrez, Jeff Pudlo: Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines. Gilead Sciences, Daryl D Muenchau, July 8, 1997: US05645985 (299 worldwide citation)

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capa ...


7
Brian Froehler, Rick Wagner, Mark Matteucci, Robert J Jones, Arnold J Gutierrez, Jeff Pudlo: Methods of using oligomers containing modified pyrimidines. Gilead Sciences, Daryl D Muenchau, November 3, 1998: US05830653 (295 worldwide citation)

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capa ...


8
Mark Matteucci: Oligonucleotide analogs with novel linkages. Gilead Sciences, Morrison & Foerster, November 23, 1993: US05264562 (295 worldwide citation)

Oligonucleotide analogs wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by an formacetal/ketal type linkage are resistant to nucleases and do not need to exhibit the diastereomerism characteristic of many other oligonucleotide analogs, and thus are capable of st ...


9
Brian C Froehler: Exonuclease-resistant oligonucleotides. Gilead Sciences, Morrison & Foerster, October 26, 1993: US05256775 (272 worldwide citation)

A method is provided for making 3' and/or 5' end-capped oligonucleotides so as to render the oligonucleotide resistant to degradation by exonucleases. The exonuclease degradation resistance is provided by incorporating two or more phosphoramidate and phosphorocmonothioate and/or phosphorodithioate l ...


10
Mark Matteucci, Robert J Jones, John Munger: Modified internucleoside linkages having one nitrogen and two carbon atoms. Gilead Sciences, Daryl D Muenchau, January 21, 1997: US05596086 (269 worldwide citation)

Oligonucleotide analogs are disclosed wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by a backbone linkage resistant to nucleases. The modified oligonucleotides are capable of strong hybridization to target RNA or DNA. The oligomers of the invention may be used ...