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Ghosh Shomir, Elder Amy M, Carson Kennth G, Sprott Kevin, Harrison Sean: Pgd2 receptor antagonists for the treatment of inflammatory diseases. Millennium Pharmaceuticals, Ghosh Shomir, Elder Amy M, Carson Kennth G, Sprott Kevin, Harrison Sean, DAVIS Steven G, April 22, 2004: WO/2004/032848 (16 worldwide citation)

Disclosed herein are compounds represented by Structural Formula (I), wherein the variables are defined herein. Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2 ('CRTH2') for the tre ...


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Ghosh Shomir, Elder Amy M, Carson Kenneth G, Sprott Kevin T, Harrison Sean J, Hicks Frederick A, Renou Christelle C, Reynolds Dominic: Pgd2 receptor antagonists for the treatment of inflammatory diseases. Millennium Pharmaceuticals, Ghosh Shomir, Elder Amy M, Carson Kenneth G, Sprott Kevin T, Harrison Sean J, Hicks Frederick A, Renou Christelle C, Reynolds Dominic, SHAIR Karoline K M, October 27, 2005: WO/2005/100321 (14 worldwide citation)

Disclosed herein are compounds represented by Structural Formula: (I) and (I-A). Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply 'CRTH2' for the treatment of inflammatory ...


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Ghosh Shomir, Raman Prakash, Sprott Kevin, Elder Amy M, Griffiths Sian, Soucy Francois, Ye Qing: Compounds useful as antagonists of ccr2. Millennium Pharmaceuticals, Ghosh Shomir, Raman Prakash, Sprott Kevin, Elder Amy M, Griffiths Sian, Soucy Francois, Ye Qing, SHAIR Karoline KM, May 10, 2007: WO/2007/053498 (14 worldwide citation)

The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammato ...


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Dai Mingshi, Jenkins Tracy J, Guan Bing, Ghosh Shomir, Minor Charles: Ccr8 inhibitors. Millennium Pharmaceuticals, Dai Mingshi, Jenkins Tracy J, Guan Bing, Ghosh Shomir, Minor Charles, DAVIS Steven G, July 15, 2004: WO/2004/058736 (11 worldwide citation)

Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I). Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a CCR8 inhibitor represented by Structural Formula (I). Also disclosed is a method of treating inflammatory ...


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Guan Bing, Minor Charles, Dai Mingshi, Ghosh Shomir, Jenkins Tracy J, Li Gang, Burdi Douglas F, Bennett Robert A: Ccr8 inhibitors. Millennium Pharmaceuticals, Guan Bing, Minor Charles, Dai Mingshi, Ghosh Shomir, Jenkins Tracy J, Li Gang, Burdi Douglas F, Bennett Robert A, DAVIS Steven G HAMILTON BROOK SMITH HAMILTON BROOK SMITH & REYNOLDS PC 530 Virginia Road PO Box 9133 Concord Massachusetts 01742 9133, July 15, 2004: WO/2004/058709 (10 worldwide citation)

Disclosed are CCR8 inhibitors represented by Structural Formulas (I). The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject ...


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Carson Kenneth G, Raman Prakash, Soucy Francois, Ye Qing, Ghosh Shomir: Compounds useful as chemokine receptor antagonists. Millennium Pharmaceuticals, Carson Kenneth G, Raman Prakash, Soucy Francois, Ye Qing, Ghosh Shomir, SHAIR Karoline K M, July 6, 2006: WO/2006/071875 (7 worldwide citation)

The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the comp ...