1
W Michael Hipps: Articulating endoscopic implant rotator surgical apparatus and method for using same. Genzyme Corporation, Richard D Allison, Thomas J DesRosier, December 19, 2000: US06162208 (450 worldwide citation)

A surgical instrument is provided for use in endoscopic and open surgical procedures, e.g., prosthetic implant replacement surgery. The instrument includes a handle portion, an endoscopic tube section extending from the handle portion, an articulating section pivotally connected to a distal end of t ...


2
Ross A Tubo, Leesa M Barone, Courtney A Wrenn: Methods and compositions for the repair of articular cartilage defects in mammals. Genzyme Corporation, July 28, 1998: US05786217 (358 worldwide citation)

Provided are methods and compositions for the repair of articular cartilage defects in a mammal. Denuded chondrogenic cells are proliferated ex vivo as monolayer cultures in order to expand the pool of available chondrogenic cells. During proliferation the chondrogenic cells stop secreting the extra ...


3
Ross A Tubo, Leesa M Barone, Courtney A Wrenn: Methods and compositions for the repair of articular cartilage defects in mammals. Genzyme Corporation, March 3, 1998: US05723331 (244 worldwide citation)

Provided are methods and compositions for the repair of articular cartilage defects in a mammal. Denuded chondrogenic cells are proliferated ex vivo as monolayer cultures in order to expand the pool of available chondrogenic cells. During proliferation the chondrogenic cells stop secreting the extra ...


4
James W Burns, Steven Cox, Alan E Walts: Water insoluble derivatives of hyaluronic acid. Genzyme Corporation, Fish & Richardson, May 21, 1991: US05017229 (172 worldwide citation)

A water insoluble, biocompatible gel that includes the reaction product of hyaluronic acid, a polyanionic polysaccharide, and an activating agent.


5
Keith E Greenawalt, Julia B Gershkovich: Compositions comprising hemostatic compounds and bioabsorbable polymers. Genzyme Corporation, Wolf Greenfield & Sacks PC, May 2, 2000: US06056970 (126 worldwide citation)

Solid, fibrous bioabsorbable hemostatic compositions containing a bioabsorbable polymer and a hemostatic compound, methods for making the hemostatic compositions, and methods for using the hemostatic compositions are disclosed.


6
Joel W Cummings, Roland Deangelis, Brian Clark, David Schiff, Paul Mulhauser, Jesse Gala: Small tissue and membrane fixation apparatus and methods for use thereof. Genzyme Corporation, Richard D Allison, Thomas J DesRosier, November 27, 2001: US06322563 (117 worldwide citation)

The present invention relates to new surgical fasteners and methods of using the surgical fasteners. The surgical fasteners of the invention are in the form of tacks and comprise generally an elongate rod, a sharp conical head, a tail, and a transverse locking member extending from the tail above th ...


7
Richard J Gregory, Donna Armentano, Larry A Couture, Alan E Smith: Adenovirus vector for gene therapy. Genzyme Corporation, Brumbaugh Graves Donohue & Raymond, September 23, 1997: US05670488 (109 worldwide citation)

Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.


8
Donald A G Mickle, Ren Ke Li, Richard D Weisel: Transplants for myocardial scars. Genzyme Corporation, Clark & Elbing, August 8, 2000: US06099832 (107 worldwide citation)

A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.


9
B Keith Wells, William R Mayfield, Gregory R Furnish: Redo sternotomy retractor. Genzyme Corporation, Needle & Rosenberg P C, December 8, 1998: US05846187 (105 worldwide citation)

A hand-held retractor that is adapted for endoscopic use at a predetermined area of a patient. The retractor is comprised of a longitudinally-extending blade with a proximal end, a distal end, and a top surface. A handle is connected to the proximal end of the blade by a separating member. The separ ...


10
Raymond Hamilton, Ellen M Fox, Raksha A Acharya, Alan E Walts: Water insoluble derivatives of hyaluronic acid. Genzyme Corporation, Fish & Richardson, June 26, 1990: US04937270 (97 worldwide citation)

A method for making a water insouble bicompatible gel includes activating HA with an activating agent to form activated HA, and reacting the activated HA with a nucleophile, under conditions producing the water insoluble bicompatible gel. Also, a method for making a water insoluble biocompatible fil ...