1
Nils Lonberg, Robert M Kay: Ransgenic non-human animals for producing heterologous antibodies. GenPharm International, Townsend & Townsend & Crew, August 13, 1996: US05545806 (1070 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...


2
Nils Lonberg, Robert M Kay: Transgenic non-human animals capable of producing heterologous antibodies of various isotypes. GenPharm International, Tracy J Dunn, William M Smith, October 29, 1996: US05569825 (951 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies of multiple isotypes. Heterologous antibodies are encoded by immunoglobulin heavy chain genes not normally found in the genome of that species of non-human animal. In one aspect of the invention, one o ...


3
Nils Lonberg, Robert M Kay: Transgenic non-human animals capable of producing heterologous antibodies. GenPharm International, Townsend and Townsend and Crew, May 27, 1997: US05633425 (910 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies, i.e., antibodies encoded by immunoglobulin heavy and light chain genes not normally found in the genome of that species of non-human animal. In one aspect of the invention, transgenes encoding unrearr ...


4
Nils Lonberg, Robert M Kay: Transgenic non-human animals for producing heterologous antibodies. GenPharm International, Townsend and Townsend and Crew, April 29, 1997: US05625126 (888 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.


5
Nils Lonberg, Robert M Kay: Transgenic non-human animals capable of producing heterologous antibodies of various isotypes. GenPharm International, Townsend and Townsend and Crew, August 26, 1997: US05661016 (833 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...


6
Nils Lonberg, Robert M Kay: Transgenic non-human animals capable of producing heterologous antibodies. GenPharm International, Townsend and Townsend and Crew, June 23, 1998: US05770429 (471 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.


7
Nils Lonberg, Robert M Kay: Transgenic non-human animals for producing heterologous antibodies. GenPharm International, Townsend and Townsend and Crew, September 29, 1998: US05814318 (376 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...


8
Nils Lonberg, Robert M Kay: Transgenic non-human animals for producing heterologous antibodies. GenPharm International, Townsend and Townsend and Crew, August 4, 1998: US05789650 (336 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...


9
Nils Lonberg, Robert M Kay: Transgenic non-human animals capable of producing heterologous antibodies of various isotypes. GenPharm International, Townsend and Townsend and Crew, March 2, 1999: US05877397 (292 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...


10
Paulus J A Krimpenfort, Antonius J M Berns: Transgenic mice depleted in a mature lymphocytic cell-type. GenPharm International, Townsend and Townsend and Crew, January 7, 1997: US05591669 (281 worldwide citation)

Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precurs ...