1
Jan G J van de Winkel, Marcus A van Dijk, Arnout F Gerritsen, Edward Halk: Human monoclonal antibodies to epidermal growth factor receptor (EGFR). Genmab, Jane E Remillard Esquire, Lahive & Cockfield, July 24, 2007: US07247301 (76 worldwide citation)

Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotyp ...


2
Teeling Jessica, Glennie Martin, Parren Paul, Gerritsen Arnout F, Ruuls Sigrid, Graus Yvo, Van de, Winkel Jan: Human monoclonal antibodies against cd20. Genmab, Teeling Jessica, Glennie Martin, Parren Paul, Gerritsen Arnout F, Ruuls Sigrid, Graus Yvo, Van de, Winkel Jan, HØIBERG, November 3, 2005: WO/2005/103081 (66 worldwide citation)

Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.


3
Teeling Jessica, Ruuls Sigrid, Glennie Martin, Van de, Winkel Jan G J, Parren Paul, Petersen Jorgen, Baadsgaard Ole D M Sc, Huang Haichun: Human monoclonal antibodies against cd20. Genmab, Teeling Jessica, Ruuls Sigrid, Glennie Martin, Van de, Winkel Jan G J, Parren Paul, Petersen Jorgen, Baadsgaard Ole D M Sc, Huang Haichun, DECONTI Giulio A, April 29, 2004: WO/2004/035607 (49 worldwide citation)

Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotype ...


4
Parren Paul, Lisby Steen, Baadsgaard Ole: Cd20 binding molecules for the treatment of copd. Genmab, Parren Paul, Lisby Steen, Baadsgaard Ole, GENMAB, January 10, 2008: WO/2008/003319 (33 worldwide citation)

Use of CD20 binding molecules, such as anti-CD20 antibodies, for the treatment of chronic obstructive pulmonary disease (COPD).


5
Van Den Brink Edward Norbert, Parren Paul, Van de Winkel Jan, Labrijn Aran Frank, Rebers Frank Everhardus Martinus, Breij Esther Cornelia Wilhelmina: Monoclonal antibodies against cd32b. Genmab, Van Den Brink Edward Norbert, Parren Paul, Van de Winkel Jan, Labrijn Aran Frank, Rebers Frank Everhardus Martinus, Breij Esther Cornelia Wilhelmina, ABILDGREN Michael, July 9, 2009: WO/2009/083009 (29 worldwide citation)

Isolated monoclonal antibodies which bind to human CD32band related antibody- based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies,and therapeutic and diagnostic methods for using the antibodies.


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Van de, Winkel Jan, Vink Tom, Schuurman Janine, Parren Paul, Aalberse Rob, Van Der Neut, Kolfschoten Marijn: Stable igg4 antibodies. Genmab, Van de, Winkel Jan, Vink Tom, Schuurman Janine, Parren Paul, Aalberse Rob, Van Der Neut, Kolfschoten Marijn, VAN DEN HAZEL Bart, December 4, 2008: WO/2008/145142 (28 worldwide citation)

The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a ...


8
Jan G J van de Winkel, Marcus A van Dijk, Janine Schuurman, Arnout F Gerritsen, Ole Baadsgaard: Human antibodies specific for interleukin 15 (IL-15). Genmab, Lahive & Cockfield, Jane E Remillard Esquire, Paul B Tran, December 26, 2006: US07153507 (27 worldwide citation)

Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing ...


9
Weers Michel de, Graus Yvo, Oprins Judith, Parren Paul Parren, Winkel Jan Van de, Vugt Martine Van: Antibodies against cd38 for treatment of multiple myeloma. Genmab, Weers Michel de, Graus Yvo, Oprins Judith, Parren Paul Parren, Winkel Jan Van de, Vugt Martine Van, HØIBERG, September 28, 2006: WO/2006/099875 (27 worldwide citation)

Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.


10
Schuurman Janine, Vink Tom, Winkel Jan Van de, Labrijn Aran Frank, Aalberse Rob, Kolfschoten Marijn Van Der Neut, Parren Paul: Bispecific antibodies and methods for production thereof. Genmab, Schuurman Janine, Vink Tom, Winkel Jan Van de, Labrijn Aran Frank, Aalberse Rob, Kolfschoten Marijn Van Der Neut, Parren Paul, GENMAB, October 9, 2008: WO/2008/119353 (26 worldwide citation)

The invention relates to an ex vivo method for the generation of a bispecific antibody, comprising the steps of: a) providing a first antibody having a first binding specificity, wherein said first antibody comprises an IgG4-like CH3 region, b) providing a second antibody having a second binding spe ...