Napoleone Ferrara, David W H Leung: Production of vascular endothelial cell growth factor and DNA encoding same. Genetech, Sean A Johnston, July 26, 1994: US05332671 (123 worldwide citation)

DNA isolates coding for a vascular endothelial cell growth factor may be used to produce the protein via recombinant expression systems. Such protein is useful therapeutically to treat conditions in which a selective action on the vascular endothelial cells, in the absence of excessive connective ti ...

Robert M Hudziak, H Michael Shepard, Axel Ullrich, Brian M Fendly: Monoclonal antibodies directed to the HER2 receptor. Genetech, Wendy M Lee, December 26, 2000: US06165464 (107 worldwide citation)

A method of inhibiting growth of tumor cells which overexpress a growth factor receptor or growth factor by treatment of the cells with antibodies which inhibit the growth factor receptor function, is disclosed. A method of treating tumor cells with antibodies which inhibit growth factor receptor fu ...

Charles W Eigenbrot, Jagath Reddy Junutula, Henry Lowman, Helga E Raab, Richard Vandlen: Cysteine engineered antibodies and conjugates. Genetech, Alex Andrus, April 21, 2009: US07521541 (97 worldwide citation)

Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design ...

Paul J Carter, Leonard G Presta, John B Ridgway: Method for making heteromultimeric polypeptides. Genetech, Wendy M Lee, October 13, 1998: US05821333 (94 worldwide citation)

The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins and antibody-immunoadhesin chimeras. The invention also relates to the heteromultimers prepared using the method. Generally, the method involves introducing a protube ...

James A Wells, Brian C Cunningham: Method for identifying active domains and amino acid residues in polypeptides and hormone variants. Genetech, Laura Terlizzi, Emily M Haliday, Skjerven Morrill MacPherson Franklin & Friel, December 3, 1996: US05580723 (87 worldwide citation)

The invention provides methods for the systematic analysis of the structure and function of polypeptides by identifying active domains which influence the activity of the polypeptide with a target substance. Such active domains are determined by substituting selected amino acid segments of the polyp ...

Gerardo A Zapata: Antibody fragments. Genetech, Wendy M Lee, May 23, 2000: US06066719 (80 worldwide citation)

This invention describes the production of bivalent linear F(ab').sub.2 fragments comprising tandem repeats of a heavy chain fragment V.sub.H -C.sub.H 1-V.sub.H -C.sub.H 1 cosecreted with two light chains, so as to form two functional antigen binding sites, wherein both the C-terminus of the first C ...

Laura C Simmons, Daniel G Yansura: Methods and compositions for secretion of heterologous polypeptides. Genetech, Walter H Dreger, Dolly A Flehr Hohbach Test Albritton & Herbert Vance, November 24, 1998: US05840523 (69 worldwide citation)

The instant invention discloses the unexpected result that mutant signal sequences with reduced translational strength provided essentially complete processing and high levels of expression of a polypeptide of interest as compared to wild type signal sequences, and that many mammalian polypeptides r ...

Ralph H Schwall, Kelly Helen Tabor: Hepatocyte growth factor receptor antagonists and uses thereof. Genetech, Steven B Kelber, Piper Marbury Rudnick & Wolfe, April 10, 2001: US06214344 (50 worldwide citation)

Hepatocyte growth factor (HGF) receptor antagonists are provided. The HGF receptor antagonists include HGF receptor antibodies and fragments thereof. The HGF receptor antagonists can be employed to block binding of HGF to HGF receptors or substantially inhibit HGF receptor activation. The HGF recept ...

Paul J Godowski, Austin L Gurney: Tie ligand homologues. Genetech, Mark T Kresnak, February 29, 2000: US06030831 (35 worldwide citation)

The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL2, NL3 and FLS139, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.

David Botstein, Audrey Goddard, Paul J Godowski, Austin L Gurney, Margaret Ann Roy, William I Wood: Secreted and transmembrane polypeptides and nucleic acids encoding the same. Genetech, Mark T Kresnak, Elizabeth M Barnes, Ginger R Dreger Esq, July 5, 2005: US06913919 (24 worldwide citation)

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to het ...