1
Shmuel Cabilly, Herbert L Heyneker, William E Holmes, Arthur D Riggs, Ronald B Wetzel: Recombinant immunoglobin preparations. Genentech, March 28, 1989: US04816567 (2628 worldwide citation)

Altered and native immunoglobulins, including constant-variable region chimeras, are prepared in recombinant cell culture. The immunoglobulins contain variable regions which are immunologically capable of binding predetermined antigens. Methods are provided for refolding directly expressed immunoglo ...


2
Daniel J Capon, Laurence A Lasky: Hybrid immunoglobulins. Genentech, Ginger R Dreger, Carolyn R Adler, May 26, 1992: US05116964 (521 worldwide citation)

Immunoglobulin fusion polypeptides are provided, together with methods for making and using them, and nucleic acids encoding them. These polypeptides are useful as cell surface adhesion molecules and ligands, and are useful in therapeutic or diagnostic compositions and methods.


3
Paul J Carter, Leonard G Presta: Immunoglobulin variants. Genentech, Wendy M Lee, October 13, 1998: US05821337 (502 worldwide citation)

Variant immunoglobulins, particularly humanized antibody polypeptides are provided, along with methods for their preparation and use. Consensus immunoglobulin sequences and structural models are also provided.


4
Paul J Carter, Leonard G Presta: Humanized antibodies and methods for making them. Genentech, Wendy M Lee, April 25, 2000: US06054297 (445 worldwide citation)

Variant immunoglobulins, particularly humanized antibody polypeptides are provided, along with methods for their preparation and use. Consensus immunoglobulin sequences and structural models are also provided.


5
Leonard Presta: Polypeptide variants with altered effector function. Genentech, Wendy M Lee, May 18, 2004: US06737056 (396 worldwide citation)

The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.


6
Paul J Carter, Leonard G Presta: Method for making humanized antibodies. Genentech, Wendy M Lee, June 18, 2002: US06407213 (372 worldwide citation)

Variant immunoglobulins, particularly humanized antibody polypeptides are provided, along with methods for their preparation and use. Consensus immunoglobulin sequences and structural models are also provided.


7
Cabilly Shmuel, Holmes William Evans, Wetzel Ronald Burnell, Heyneker Herbert Louis, Riggs Arthur Dale: Recombinant immunoglobulin preparations, methods for their preparation, dna sequences, expression vectors and recombinant host cells therefor.. Genentech, Hope City, November 14, 1984: EP0125023-A1 (370 worldwide citation)

Recombinant DNA techniques are used to produce both immunoglobulins which are analogous to those normally found in vertebrate systems and to take advantage of these gene modification techniques to construct chimeric or other modified forms.


8
Shmuel Cabilly, Herbert L Heyneker, William E Holmes, Arthur D Riggs, Ronald B Wetzel: Methods of producing immunoglobulins, vectors and transformed host cells for use therein. Genentech, Burns Doane Swecker & Mathis, December 18, 2001: US06331415 (328 worldwide citation)

The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains o ...


9
Esohe Ekinaduese Idusogie, Leonard G Presta, Michael George Mulkerrin: Polypeptide variants. Genentech, Wendy M Lee, February 27, 2001: US06194551 (321 worldwide citation)

A variant of a polypeptide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at amino acid position 329, or at two or all of amino acid positions 329, 331 and 322 of the human IgG Fc region. Such variants display altered effector function. For example, ...


10
Lisa J Garrard, Dennis J Henner, Steven Bass, Ronald Greene, Henry B Lowman, James A Wells, David J Matthews: Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants. Genentech, Daryl B Winter, Walter H Dreger, May 12, 1998: US05750373 (317 worldwide citation)

A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat pro ...



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