1
Daniel L Kacian, Timothy J Fultz: Nucleic acid sequence amplification methods. Gen Probe Incorporated, Lyon & Lyon, March 21, 1995: US05399491 (528 worldwide citation)

Methods of synthesizing multiple copies of a target nucleic acid sequence autocatalytically under conditions of substantially constant temperature, ionic strength, and pH are provided in which multiple RNA copies of the target sequence autocatalytically generate additional copies. These methods are ...


2
Daniel L Kacian, Diane L McAllister, Sherrol H McDonough, Nanibhushan Dattagupta: Nucleic acid sequence amplification method, composition and kit. Gen Probe Incorporated, Lyon & Lyon, September 10, 1996: US05554516 (231 worldwide citation)

A method, composition and kit for amplifying a target nucleic acid sequence under conditions of substantially constant temperature, ionic strength, and pH and using only a single promoter-primer. To effect the amplification, a supply of a single promoter-primer having a promoter and a primer complem ...


3
Lyle J Arnold Jr, Mark A Reynolds, Ram S Bhatt: Linking reagents for nucleotide probes. Gen Probe Incorporated, Lyon & Lyon, December 17, 1996: US05585481 (218 worldwide citation)

A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Su ...


4
Robert Wang: Magnetic separation rack for diagnostic assays. Gen Probe Incorporated, Lyon & Lyon, January 23, 1990: US04895650 (204 worldwide citation)

A magnetic separation rack and method for separating magnetically attractable particles used in an assay technique such as a heterogeneous diagnostic assay. The rack has a plurality of test tubes holders and a series of magnets positioned so that each test tube has one and only one magnetic immediat ...


5
Lyle J Arnold Jr, Norman C Nelson: Homogenous protection assay. Gen Probe Incorporated, Lyon & Lyon, February 1, 1994: US05283174 (174 worldwide citation)

Improved homogenous diagnostic assay methods and labels for detecting an analyte in a medium when the analyte is a member of a specific binding pair. The methods and labels provide procedures for reducing background and increasing sensitivity. The binding partner of the analyte is labeled with a sub ...


6
William G Weisburg, Jay H Shaw, Michael M Becker, Mehrdad Majlessi: Two-step hybridization and capture of a polynucleotide. Gen Probe Incorporated, Christine A Gritzmacher, Carlos A Fisher, August 29, 2000: US06110678 (173 worldwide citation)

A method for capturing a target polynucleotide in a sample onto a solid support with an attached immobilized probe by using a capture probe and two different hybridization conditions, which preferably differ in temperature only, is disclosed. The two hybridization conditions control the order of hyb ...


7
David E Kohne: Method for detecting, identifying, and quantitating organisms and viruses. Gen Probe Incorporated, Lyon & Lyon, February 22, 1994: US05288611 (172 worldwide citation)

A method and probes for specifically and sensitively detecting, identifying, and quantitating any organism category or group of organisms containing RNA in a sample is disclosed. The nucleic acids of the organisms present in the sample are brought together with a marked probe comprising nucleic acid ...


8
Kelly G Ammann, Ralph E Burns, Ernest V Hansberry, Glenn A Horner, Cheryl A Jakub, John E Kling, Donald J Nieglos, Robert E Schneider, Robert J Smith: Automated process for isolating and amplifying a target nucleic acid sequence. Gen Probe Incorporated, Charles B Cappellari, Rothwell Figg Ernst & Manbeck, January 1, 2002: US06335166 (144 worldwide citation)

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample ...


9
Daniel L Kacian, Timothy J Fultz: Nucleic acid sequence amplification methods. Gen Probe Incorporated, Lyon & Lyon, January 2, 1996: US05480784 (137 worldwide citation)

Methods of synthesizing multiple copies of a target nucleic acid sequence autocatalytically under conditions of substantially constant temperature, ionic strength, and pH are provided in which multiple RNA copies of the target sequence autocatalytically generate additional copies. Nucleotide sequenc ...


10
Kelly G Ammann, Ralph E Burns, Ernest V Hansberry, Glenn A Horner, Cheryl A Jakub, John E Kling, Donald J Nieglos, Robert E Schneider, Robert J Smith: Method and apparatus for performing a magnetic separation purification procedure on a sample solution. Gen Probe Incorporated, Charles B Cappellari Esq, Rothwell Figg Ernst & Manbeck P C, August 12, 2003: US06605213 (135 worldwide citation)

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample ...