1
Lauffer Leander Dr, Oquendo Patricia Dr, Zettlmeissl Gerd Dr, Seed Brian Dr: Fusionproteins with parts of immunoglobulins, their production and use.. Behringwerke, Gen Hospital, January 8, 1992: EP0464533-A1 (123 worldwide citation)

The invention relates to genetically engineered soluble fusion proteins consisting of human proteins or parts thereof not belonging to the immunoglobulin family and various portions of the constant region of immunoglobulin molecules. The functional properties of both fusion components are surprising ...


2
Aruffo Alejandro A, Ledbetter Jeffrey A, Noell Randolph, Stamenkovic Ivan: The cd40cr receptor and ligands therefor.. Squibb Bristol Myers Co, Dartmouth College, Gen Hospital, August 18, 1993: EP0555880-A2 (98 worldwide citation)

The present invention relates to a counter-receptor, termed CD40CR, for the CD40 B-cell antigen, and to soluble ligands for this receptor, including fusion molecules comprising at least a portion of CD40 protein. It is based, at least in part, on the discovery that a soluble CD40/immunoglobulin fusi ...


3
Brian Seed Dr: Cloned genes encoding ig-cd4 fusion proteins and the use thereof.. Gen Hospital, July 26, 1989: EP0325262-A2 (97 worldwide citation)

Fusion proteins of immunoglobulins of the IgM, IgG1 or IgG3 class, wherein the variable region of the light or heavy chain has been replaced with CD4 or fragments thereof capable of binding to gp120 or immunoglobulin-like molecules comprising such fusion proteins together with an immunoglobulin ligh ...


4
Breakfield Xandra O, Martuza Robert L: Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication.. Gen Hospital, October 23, 1991: EP0453242-A1 (93 worldwide citation)

Methods of gene delivery to cells in the central nervous system are disclosed by introducing and expressing gene sequences mediated by herpes simplex virus 1 (HSV-1) vectors with a mutation in a gene for viral replication.


5
Seed Brian Dr Department Of Mo, Allen Janet, Aruffo Alejandro, Camerini David, Lauffer Leander Dr, Oquendo Carmen Patricia, Simmons David, Stamenkovic Ivan, Stengelin Siegfried Dr: Rapid immunoselection cloning method.. Gen Hospital, August 30, 1989: EP0330191-A2 (60 worldwide citation)

A simple and highly efficient method for cloning cDNAs from mammalian expression libraries based on transient expression in mammalian host cells has been discovered. Novel expression vectors allowing highly efficient construction of mammalian cDNA libraries are disclosed. The cloning method of the i ...


6
Matsueda Gary R, Haber Edgar: A method of screening hybridomas.. Gen Hospital, December 16, 1987: EP0249007-A2 (55 worldwide citation)

The invention relates to a method of screening for hybridomas that secrete fibrin clot-specific monoclonal antibodies.


7
Martuza Robert L, Coen Donald M: Viral mediated destruction of neoplastic cells.. Gen Hospital, November 25, 1992: EP0514603-A1 (41 worldwide citation)

Compositions and methods for selectively killing neoplastic cells are disclosed which utilise altered viruses that are capable of replication in neoplastic cells while sparing surrounding normal tissue.


8
Ford Alan D, Sims Nathaniel M, Mandro Marc A: An infusion pump with an electronically loadable drug library.. Gen Hospital, Baxter Int, April 26, 1995: EP0649316-A1 (35 worldwide citation)

A system for creating a customized drug library for an electronically loadable drug infusion pump, the system including a drug library containing a plurality of drug entries, there being associated with each drug entry a set of associated drug delivery parameters and/or drug delivery protocols for c ...


9
Pfitzner Ursula M, Pfitzner Arthur P, Goodman Howard M Prof: Pathogenesis-related proteins in plants.. Gen Hospital, March 22, 1989: EP0307841-A1 (33 worldwide citation)

This invention is directed to the regulatory sequences of the pathogenesis-related (PR) protein genes of the PR-1 group, specifically an inducible PR-1 promoter and, preferably, PR-1 secretion signal sequences, and to genetic constructs containing the regulatory sequences. This invention also relate ...


10
Anderson R Rox, Farinelli William, Grossman Melanie: Hair removal method using optical pulses. Gen Hospital, July 3, 2002: EP1219258-A1 (30 worldwide citation)

A method for simultaneously effecting the removal of multiple hairs from a skin region by using light energy to destroy hair follicles in the region is disclosed. Light energy is applied to the region through an applicator which converges the light energy to enhance destruction of desired portions o ...