Lucia G I Marshall, Kanaiyalal R Patel, Dikla G Roufa: Controlled release formulations of trophic factors in ganglioside-lipsome vehicle. G D Searle & Co, J Timothy Keane, Paul D Matukaitis, Cynthia S Kovacevic, December 17, 1991: US05073543 (355 worldwide citation)

A formulation is described for systemic delivery and controlled release of a trophic factor. The formulation comprises a glycolipid carrier component which delivers trophic factor, such as nerve growth factor, to a target organ. The glycolipid carrier protects the trophic factor from degradation by ...

Joseph H Schulman: Rechargeable tissue stimulating system. G D Searle & Co, Walter C Ramm, Charles H Thomas Jr, Peter J Sgarbossa, March 9, 1976: US03942535 (260 worldwide citation)

A rechargeable tissue stimulating system with a telemetry controlled power source. A constant current power source acting through an induction coil externally located with respect to a living patient is used to induce current flow in a charging circuit located beneath the skin of the patient. The ch ...

George Ferdinand Rowland: Immunological materials. G D Searle & Co, John J McDonnell, September 6, 1977: US04046722 (174 worldwide citation)

The present invention is concerned with a cytotoxic agent comprising an immunoglobulin specific for antigens on the surface of the cell to be killed having 1-10 polymer carrier molecules covalently bonded thereto and the polymer carrier having 5-500 molecules of a cytotoxic drug covalently bound. Th ...


Albert S Waxman: Ultrasound imaging system with improved scan conversion. G D Searle & Co, Walter C Ramm, Albert Tockman, Dennis O Kraft, November 15, 1977: US04058001 (126 worldwide citation)

In an improved system for medical imaging employing a transducer for transmitting and detecting ultrasonic vibrations, a digital scan converter accepts echo signals detected by the transducer and transducer position signals identifying the point of origin of the signals in a scanning plane transvers ...

John J Talley, Thomas D Penning, Paul W Collins, Donald J Rogier Jr, James W Malecha, Julie M Miyashiro, Stephen R Bertenshaw, Ish K Khanna, Matthew J Graneto, Roland S Rogers, Jeffery S Carter: Substituted pyrazolyl benzenesulfonamides. G D Searle & Co, Joseph W Bulock, J Timothy Keane, November 14, 1995: US05466823 (117 worldwide citation)

A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.

Yie W Chien, Howard J Lambert: Method for making a microsealed delivery device. G D Searle & Co, John J McDonnell, November 16, 1976: US03992518 (103 worldwide citation)

The present invention is concerned with a pharmaceutical delivery device comprising a biologically acceptable silicone polymer matrix having microsealed compartments of 10-200 microns throughout, wherein the microsealed compartments contain a pharmaceutical in a hydrophilic solvent system. The biolo ...

Abramson Harvey J: Intrauterine contraceptive devices and inserters therefor. G D Searle & Co, December 11, 1973: US3777748 (103 worldwide citation)

The present invention relates to intrauterine contraceptive devices in the general shape of a '7' having a transverse arm and a longitudinal arm dependent substantially from an end thereof; method of contraception by insertion of such a device into the uterus; instruments and methods for the inserti ...

Melvin L Krzeminski: Instrument for loading an intrauterine device into an insertion tube. G D Searle & Co, James R Henes, February 10, 1981: US04249525 (95 worldwide citation)

An instrument adapted for collapsing the extended arms of a T-shaped intrauterine device and loading the collapsed device into an insertion tube is disclosed.

Steven P Adams, Larry P Feigen, Masateru Miyano: Novel platelet-aggregation inhibitor peptide derivatives. Monsanto Company, G D Searle & Co, Scott J Meyer, James W Williams Jr, August 15, 1989: US04857508 (88 worldwide citation)

Novel tetrapeptide derivatives are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the sequence X-Gly-Asp-Y wherein X is illustrated by arginine and Y is illustrated by O-methyltyrosine amide.