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Keiji Hemmi, Masahiro Neya, Keisuke Imai, Natsuko Kayakiri, Masashi Hashimoto: Renin inhibitor peptide compounds, a process for the preparation thereof and pharmaceutical composition comprising the same. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, October 16, 1990: US04963530 (109 worldwide citation)

A compound of the formula: ##STR1## wherein R.sup.1 is aryl optionally substituted with a substituent selected from the group consisting of halogen and halo(lower)alkyl; lower alkyl or cyclo(lower)alkyl; and


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Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka: Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, January 16, 1990: US04894366 (104 worldwide citation)

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a pr ...


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Masaaki Matsuo, Daijiro Hagiwara, Hiroshi Miyake: Peptide compounds having substance P antagonism, processes for preparation thereof and pharmaceutical composition comprising the same. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, November 17, 1992: US05164372 (67 worldwide citation)

Peptide compounds having Substance P antagonism of the formula: ##STR1## wherein R.sup.1 is lower alkyl, aryl, arylamino, pyridyl, pyrrolyl, pyrazolopyridyl, quinolyl, or a group of the formula: ##STR2## wherein the symbol of a line and dotted line is a single bond or a double bond; X is CH or N; Z ...


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Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka: Method for immunosuppression. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, May 29, 1990: US04929611 (58 worldwide citation)

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a pr ...


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Yoshinari Sato, Teruaki Matuo: Benzodiazepine derivatives. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, November 13, 1990: US04970207 (32 worldwide citation)

This invention relates to new benzodiazepine derivatives and pharmaceutically acceptable salts thereof. More particularly, it relates to new benzodiazepine derivatives and pharmaceutically acceptable salts thereof which are cholecystokinin (CCK) antagonists and therefore can be used as therapeutical ...


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Ikuo Ueda, Mineo Niwa, Yoshimasa Saitoh, Susumu Satoh, Chihiro Kusunoki, Tadashi Kitaguchi, Hiroki Ono: IGF-I fusion proteins; protection of IGF-I from degradation by host cell; and processes for the production thereof. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, July 2, 1991: US05028531 (28 worldwide citation)

IGF-I fused with a protective peptide, in which the protective peptide is a protein peptide and is used for the protection of IGF-I from degradation by protease in cells of E. coli is disclosed. Also disclosed are genes coding for the fused IGF-I's, plasmids containing the genes, and E. coli microor ...


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Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga: Pharmaceutically useful pyrazolopyridines. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, May 15, 1990: US04925849 (22 worldwide citation)

The disclosure deals with a pyrazolopyridine compound of the formula ##STR1## wherein the variables are defined in the specification. The compounds are useful as a diuretic, antihypertensive agent, etc.


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Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga: Method of treatment using pyrazolopyridine compound. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, October 13, 1992: US05155114 (22 worldwide citation)

The invention relates to a method for the prevention and/or treatment of renal toxicity, nephrosis or nephritis, which comprises administering a pyrazolopyridine compound of the formula: ##STR1## wherein R.sup.1 is aryl, and


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