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Pyrrolobenzodiazepinone derivatives. Fujisawa Pharmaceutical Co, December 6, 1972: GB1299198-A (37 worldwide citation)

1299198 Antibiotic pyrrolobenzodiazepinone derivatives FUJISAWA PHARMACEUTICAL CO Ltd 24 Dec 1969 [30 Dec 1968 26 June 1969] 62863/69 Heading C2A Novel pyrrolobenzodiazepinone derivatives having the Formula (I) wherein R 1 is H, C 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyl, aryl-C 1 -C 6 alkylcarbonyl, or ...


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Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara, Kazuo Sakane, Kohji Kawabata, Hidenori Ohki: Cyclic polypeptide with antibiotic activity, process for its preparation and pure culture of a coelomycetes strain.. Fujisawa Pharmaceutical Co, December 27, 1991: EP0462531-A2 (36 worldwide citation)

A polypeptide compound of the following general formula : wherein R is hydrogen or acyl group, R is hydroxy or acyloxy, R is hydrogen or hydroxysulfonyloxy, and R is hydrogen or carbamoyl, with proviso that (i) R is acyloxy, when R is hydrogen, and (ii) R is not palmitoyl, when R is hydroxy, R is hy ...


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Okuhara Masakuni, Goto Toshio, Hori Yasuhiro, Fujita Takashi, Ueda Hirotsugu, Shigematsu Nobuharu: Fr901228 substance and preparation thereof.. Fujisawa Pharmaceutical Co, January 31, 1990: EP0352646-A2 (36 worldwide citation)

FR9012228 substance of the following formula, process for its production and pharmaceutical compositions comprising it as an active ingredient. The invention also comprises a biologically pure culture of Chromobacterium violaceum WB968 (FERM BP-1968).


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Seizo Sunago, Osamu Takahata, Akira Kagayama, Hitoshi Futagawa, Tetsuji Miyamoto, Mitsuo Murakami: Fluid vessel. Fujisawa Pharmaceutical, Nissho Corporation, Oblon Spivak McClelland Maier & Neustadt P C, October 27, 1998: US05826713 (35 worldwide citation)

A fluid vessel including a drug vessel with a mouth portion sealed with a penetrable plug, a vial guide which holds the drug vessel and a flexible solvent vessel. The flexible solvent vessel has a drug solution outlet port and a communication port to the drug vessel, and an integrally molded tubular ...


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Saburo Murata, Fumio Shiomojo, Yuji Tokunaga, Takehisa Hata: Aerosol compositions. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, March 26, 2002: US06361760 (35 worldwide citation)

The use of a medium-chain fatty acid triglyceride as the dispersant in the preparation of a medicinal aerosol composition comprising tricyclic compound (I) dispersed in a liquefied hydrofluoroalkane propellant is described. When a liquefied hydrofluoroalkane is added to a kneaded premix of the tricy ...


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Masakuni Okuhara, Toshio Goto, Yasuhiro Hori, Takashi Fujita, Hirotsugu Ueda, Nobuharu Shigematsu: FR901228 substance and preparation thereof. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, December 11, 1990: US04977138 (35 worldwide citation)

The invention relates to a compound having antimicrobial and antitumor activity, the compound being designated FR901228 substance of the following formula: ##STR1##


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Norihiko Shimazaki, Keiji Hemmi, Osamu Nakaguti, Yoshio Miyazaki, Masashi Hashimoto: Piperazine compound as PAF-antagonist. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, July 10, 1990: US04940709 (34 worldwide citation)

Diseases caused by platelet activating factor are prevented and treated by administration to a subject of a therapeutically effective amount of a piperazine compound of the formula: ##STR1## wherein R.sup.1 to R.sup.4 are as defined in the specification.


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Hiroyuki Setoi, Takehiko Ohkawa, Tatsuya Zenkoh, Keiji Hemmi, Hirokazu Tanaka: Benzamide derivatives and pharmaceutical composition comprising the same. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, May 28, 1996: US05521170 (34 worldwide citation)

Compounds having the structure below ##STR1## and pharmaceutically acceptable salts thereof exhibit vasopressin antagonistic activity, vasodilating activity, hypotensive activity, activity for inhibiting saccharide release in the liver, activity for inhibiting growth of mesagium cells, water diureti ...


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Teruo Oku, Hiroshi Kayakiri, Shigeki Satoh, Yoshito Abe, Yuki Sawada, Takayuki Inoue, Hirokazu Tanaka: Bradykinin antagonist quinolines. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, October 8, 1996: US05563162 (33 worldwide citation)

This invention relates to new heterocyclic compounds and pharmaceutically acceptable salts thereof. More particularly, this invention relates to new heterocyclic compounds and salts thereof which display bradykinin antagonist activity, to processes for preparing these compounds, to a pharmaceutical ...