51
Kasahara Chiyoshi, Ohkawa Takehiko, Hashimoto Masashi: Tetrahydropyrane compounds, a process for their production and a pharmaceutical composition containing the same. Fujisawa Pharmaceutical Co, March 4, 1992: GB2247456-A (43 worldwide citation)

Compounds of the formula: wherein R is hydroxy and R is hydrogen, hydroxy, alkoxy or acryloxy, or R @@@and R are combined to form oxa, R is alkyl, ar(lower)alkyl or protected carboxy(lower)alkyl, R is hydroxy or alkoxy, A is methylene, hydroxymethylene or carbonyl, and n is an integer of 1 or 2, or ...


52
Seizo Sunago, Osamu Aoki: Transfusion device. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, October 4, 1994: US05352191 (40 worldwide citation)

A transfusion device comprising a flexible vessel containing a solvent fluid, a plugged drug container containing a drug, and a communicating portion for communicating the vessel and the container with each other, the communicating portion comprising a communicating passage disposed at a top portion ...


53
Hideo Yagi, Toru Takeuchi: Concrete admixture. Fujisawa Pharmaceutical, Oblon Fisher Spivak McClelland & Maier, February 28, 1989: US04808641 (40 worldwide citation)

The invention relates to an admixture to be used in preparing a fresh concrete with enhanced flowability and air-entraining property.


54
Noriko Oku legal representative, Chikako Oku legal representative, Tomohito Oku legal representative, Hiroshi Kayakiri, Yoshito Abe, Hitoshi Hamashima, Hitoshi Sawada, Naoki Ishibashi, Hiroyuki Setoi, Noritsugu Yamasaki, Takafumi Imoto, Takahiro Hiramura: Imidazole compounds and medicinal use thereof. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, June 13, 2006: US07060721 (39 worldwide citation)

Imidazole compounds represented by general formula (I): wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided. These compounds are useful in treating the diseases curable based on a hypoglycemic action, and the diseas ...


55
Teruo Oku, Chiyoshi Kasahara, Takehiko Ohkawa, Masashi Hashimoto: Oxaspiro�2,5! octane derivative. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, June 16, 1998: US05767293 (39 worldwide citation)

Oxaspiro�2,5! octanes of the formula ##STR1## inhibit angiogenesis and are particularly suitable for the treatment of solid tumors. In preferred embodiments, R.sup.1 is a carbamoyl derivative, R.sup.2 is an alkoxy substituent and R.sup.3 is ##STR2## Pharmaceutical salts of these compounds, such as m ...


56
Ueda Ikuo, Shiokawa Youichi, Take Kazuhiko, Itani Hiromichi: Imidazoheterocyclic compounds processes for preparation thereof and pharmaceutical compositions comprising them.. Fujisawa Pharmaceutical Co, December 10, 1986: EP0204285-A1 (39 worldwide citation)

Imidazoheterocyclic compounds of the formula: wherein R is lower alkenyl, lower alkynyl, lower alkadienyl, lower alkenyloxy (lower) alkyl, lower alkynyloxy(lower)alkyl, carboxy(lower)alkynyloxy(loweralkyl or protected carboxy(lower)alkynyloxy(lower)alkyl, R is hydrogen, lower alkyl or aryl, R is ar( ...


57
Oku Teruo, Setoi Hiroyuki, Kayakiri Hiroshi, Satoh Shigeki, Inoue Takayuki, Saitoh Yuki, Kuroda Akio, Tanaka Hirokazu: Imidazole derivatives, potent and selective antagonists of angiotensin ii receptor.. Fujisawa Pharmaceutical Co, April 15, 1992: EP0480204-A1 (38 worldwide citation)

A compound of the formula : wherein R is hydrogen, halogen, nitro, lower alkyl, lower alkoxy, amino or acylamino, R, R and R are each hydrogen, halogen, nitro, cyano, lower alkyl, lower alkenyl, lower alkylthio, more or di or trihalo(lower)alkyl, oxo(lower)alkyl, hydroxy(lower)alkyl or optionally es ...


58

59
Shiokawa Youichi, Takimoto Koichi, Takenaka Kohei, Kato Takeshi: Benzopyran derivatives and processes for preparation thereof.. Fujisawa Pharmaceutical Co, October 3, 1990: EP0389861-A1 (38 worldwide citation)

A compound of the formula : wherein R and R are each lower alkyl, R is hydroxy or acyloxy and R is hydrogen, or R and R are linked together to form a bond, R is hydrogen or lower alkyl and R is hydrogen, lower alkyl or aryl, or R and R are linked together to form lower alkylene, R is cyano, acyl, ha ...


60
Yoshio Kawai, Hitoshi Yamazaki, Natsuko Kayakiri, Kousei Yoshihara, Takumi Yatabe, Teruo Oku: Benzofuran derivatives useful as inhibitors of bone resorption. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, January 12, 1999: US05858995 (38 worldwide citation)

This invention relates to a novel heterocyclic compound represented by formula (I), wherein each symbol is as defined in the specification and a pharmaceutically acceptable salt thereof which are the inhibitors of bone resorption and bone metabolism, to processes for preparation thereof, to a pharma ...