41
Yoshio Ueda, Fumio Shimojo, Yasuo Shimazaki, Kazutake Kado, Toshiyasu Honbo: Solid dispersion composition of FR-900506 substance. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, April 10, 1990: US04916138 (50 worldwide citation)

This invention relates to a solid dispersion composition comprising FR-900506 substance and water-soluble hydroxypropyl methylcellulose which is capable of dispersing the FR-900506 substance, the FR-900506 substance and hydroxypropyl methylcellulose being in the ratio of 1:0:1 to 1:20 by weight.


42
Yoshinari Sato, Kazuo Sakane, Seiichiro Tabuchi, Hitoshi Mitsui, Ikuyo Katsumi, Yuichi Satoh: Benzodiazepine derivatives. Fujisawa Pharmaceutical, Nippon Shokubai, Oblon Spivak McClelland Maier & Neustadt P C, June 9, 1998: US05763437 (50 worldwide citation)

Benzodiazepine derivatives of formula (I) wherein R.sup.1 is aryl which may have one or more suitable substituent(s), R.sup.2 is C.sub.3 -C.sub.8 cycloalkyl which may have one or more suitable substituent(s), A is lower alkylene, R.sup.3 is a heterocyclic group selected from the group consisting of ...


43
Ohkawa Takehiko, Imamura Kenichiro, Kurosaki Toshio, Kobayashi Motoo, Shimizu Shiho: Pyrrolidine, thiazolidine and oxazolidine compounds which inhibit dipeptidyl peptidase-iv (dpp). Fujisawa Pharmaceutical, Ohkawa Takehiko, Imamura Kenichiro, Kurosaki Toshio, Kobayashi Motoo, Shimizu Shiho, UEKI Kyuichi, December 23, 2004: WO/2004/111041 (50 worldwide citation)

A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X is cyano or H; Y is CH?2#191, O, S, SO or SO?2# Z is (lower)alkylene, and the like; R¿1? and R¿2? are linked together to form (lower)alkylene or (lower)alkenylene, and R¿3? is H, (lower)alkyl or hydroxy; ...


44
Oku Teruo, Setoi Hiroyuki, Kayakiri Hiroshi, Inoue Takayuki, Kuroda Akio, Katayama Akira, Hashimoto Masashi, Satoh Sigeki, Tanaka Hirokazu: Condensed imidazole derivatives and processes for preparation thereof.. Fujisawa Pharmaceutical Co, May 8, 1991: EP0426021-A1 (48 worldwide citation)

A compound of the formula : wherein R is lower alkyl, halo(lower)alkyl, cyclo(lower)alkyl or lower alkylthio, R is hydrogen or imino-protective group, R is hydrogen or halogen, A is lower alkylene, and is a group of the formula : in which X, X, X and X are each N or CR, in which R is hydrogen, lower ...


45
Matsuo Masaaki, Ogino Takashi, Igari Norihiro, Seno Hachiro, Shimomura Kyoichi: Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same.. Fujisawa Pharmaceutical Co, February 13, 1991: EP0412404-A2 (47 worldwide citation)

A compound of the formula : wherein R is hydrogen or acyl which may be substituted with halogen, R is hydrogen, lower alkyl, hydroxy(lower)alkyl, halogen or carboxy, A is -CH2-, -CO-, -C(=NOR)- [wherein R is lower alkyl, [wherein m is 0, 1 or 2], and R is aryl which may be substituted with halogen, ...


46
Matsuo Masaaki, Hagiwara Daijiro, Miyake Hiroshi: Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same.. Fujisawa Pharmaceutical Co, April 29, 1992: EP0482539-A2 (46 worldwide citation)

A compound of the formula : wherein R is lower alkyl, aryl, arylamino, pyridyl, pyrrolyl, pyrazolopyridyl, quinolyl, or a group of the formula : wherein the symbol of a line and dotted line is a single bond or a double bond, X is CH or N, and Z is O, S or NH, each of which may have suitable substitu ...


47
Urano Yasuharu, Hosaka Mitsuru, Inoue Takayuki, Osoda Kazuhiko, Sawada Kozo, Kuroda Akio: (hdac) Inhibitors. Fujisawa Pharmaceutical, Urano Yasuharu, Hosaka Mitsuru, Inoue Takayuki, Osoda Kazuhiko, Sawada Kozo, Kuroda Akio, TAKASHIMA Hajime, August 26, 2004: WO/2004/072047 (46 worldwide citation)

A compound of the following formula (I):whereinR1 is acyl, R2 is hydrogen, orR1 and R2 are linked together to form a heterocyclic ring, R5 is hydroxy, hydroxylamino, lower alkyl, lower alkoxy, halo(lower)alkyl or hydroxy(lower)alkyl, Q is lower alkylene or lower alkenylene, andG is a substituent sel ...


48
Yamasaki Noritsugu, Imoto Takafumi, Murai Yoshiyuki, Hiramura Takahiro, Oku Teruo, Sawada Kouzou: Benzimidazole derivatives. Fujisawa Pharmaceutical Co, December 9, 1998: EP0882718-A1 (44 worldwide citation)

Novel benzimidazole derivatives represented by the formula (I): wherein R3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceutically acceptable salts. Because of their blood sugar-depressing effect or ...


49

50
Oku Teruo, Kayakiri Hiroshi, Satoh Shigeki, Abe Yoshito, Sawada Yuki, Inoue Takayuki, Tanaka Hirokazu: Heterocyclic compounds as bradykinin antagonists.. Fujisawa Pharmaceutical Co, November 2, 1994: EP0622361-A1 (43 worldwide citation)

A compound of the formula : wherein X is N or C-R, X is N or C-R, X is N or C-R, R is hydrogen or halogen, R is halogen, R is hydrogen, nitro, amino optionally having suitable substituent(s) or a heterocyclic group optionally having suitable substituent(s), R and R are each hydrogen or halogen, R an ...