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Masaaki Matsuo, Daijiro Hagiwara, Hiroshi Miyake: Peptides having tachykinin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same.. Fujisawa Pharmaceutical Co, August 28, 1991: EP0443132-A1 (56 worldwide citation)

A compound of forumula: wherein R is aryl, or a group of the formula : wherein X is CH or N, and Z is O or N-R, in which R is hydrogen or lower alkyl, R is hydroxy or lower alkoxy, R is hydrogen or lower alkyl which may have suitable substituent(s), R is ar(lower)alkyl which may have suitable substi ...


32
Ueda Ikuo, Matsuo Masaaki, Satoh Susumu, Watanabe Takao: 2-oxo-benzothiazoline, benzoxazoline or indoline derivatives, their preparation, and pharmaceutical compositions comprising such derivatives.. Fujisawa Pharmaceutical Co, January 14, 1981: EP0022317-A1 (55 worldwide citation)

Compounds having the formula: wherein R1_ is hydroxy, halogen, nitro, amino, cycloalkyl having from 3 to 8 carbon atoms, aryl or aryloxy which may be substituted with halogen, R is hydrogen, halogen or lower alkyl, R is carboxy or protected carboxy, Ya is sulfur, oxygen or methylene, and A is lower ...


33
Oku Teruo, Kawai Yoshio, Marusawa Hiroshi, Yamazaki Hitoshi, Abe Yoshito, Tanaka Hirokazu: Condensed pyrazole derivatives with interleukin-1 and tumour necrosis factor inhibitory activity.. Fujisawa Pharmaceutical Co, March 17, 1993: EP0531901-A2 (55 worldwide citation)

1. A compound of the formula : wherein R is aryl which may have suitable substituent(s) or heterocyclic group which may have suitable substituent(s), R is aryl which may have suitable substituent(s) or heterocyclic group which may have suitable substituent(s), and Y is a bivalent radical selected fr ...


34

35
Aoki Osamu, Okada Kiyonori, Sunaga Seizo, Futagawa Hitoshi, Ideka Kohji, Hasegawa Shuji: Fluid container.. Nissho, Fujisawa Pharmaceutical Co, October 4, 1989: EP0335378-A2 (54 worldwide citation)

A fluid container comprising a flexible bag (1) containing a diluent and having a closing film at its upper end, a capsule (2) connected to the flexible bag, a drug container (3) held in the capsule and a communicating means (16) communicating the flexible bag with the drug container. The communicat ...


36
Yoshikuni Itoh, Kazuhiko Ohne, Hirokazu Tanaka: Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same.. Fujisawa Pharmaceutical Co, November 11, 1992: EP0512570-A1 (54 worldwide citation)

A compound of the formula : wherein R is aryl which may be substituted with halogen, nitro, amino, lower alkylamino, lower alkoxy or acylamino, R is hydrogen; alkyl; cycloalkyl; or lower alkyl which is substituted with cyclo(lower)alkyl, cyclo(lower)alkenyl, a heterocyclic group or aryl optionally s ...


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Oku Teruo, Kayakiri Hiroshi, Satoh Shigeki, Abe Yoshito, Yuki Sawada, Tanaka Hirokazu: Imidazo (1,2-a) pyridines as bradykinin antagonists.. Fujisawa Pharmaceutical Co, May 11, 1994: EP0596406-A1 (54 worldwide citation)

A compound of the formula : wherein R is halogen, R and R are each hydrogen, lower alkyl, halo(lower)alkyl or acyl, R is aryl having suitable substituent(s), or a heterocyclic group optionally having suitable substituent(s), Q is O or N-R, in which R is hydrogen or acyl, and A is lower alkylene, and ...


38
Akira Kagayama, Sumihisa Kimura, Saburo Murata, Sachiyo Tanimoto, Takehisa Hata: Sustained release medicinal preparation. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, February 11, 1997: US05601844 (53 worldwide citation)

A sustained release medicinal preparation is produced by enclosing a macrocyclic compound represented by 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylviny l)-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1 .0.sup.4,9 ]octacos-18-ene-2,3,10,16-tetraon ...


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Toshinobu Uemura, Kiyohide Shinooka, Tokuaki Kajiho: Sustained release tablet. Fujisawa Pharmaceutical, Oblon Fisher Spivak McClelland & Maier, September 22, 1987: US04695467 (52 worldwide citation)

The invention relates to a sustained release tablet which comprises easily disintegrable granules containing


40
Teruo Oku, Kozo Sawada, Akio Kuroda, Kazuhiko Ohne, Atsushi Nomoto, Naomi Hosogai, Yoshimitsu Nakajima, Akira Nagashima, Keizo Sogabe, Kouichi Tamura, Masakazu Kobayashi: Indole derivatives as cGMP-PDE inhibitors. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, May 30, 2000: US06069156 (51 worldwide citation)

Compounds of the formula (I): ##STR1## and their pharmaceutically acceptable compositions are useful in inhibiting the activity of cyclic guanosine 3',5'-monophosphate phosphodiesterase.