1
Yoshihiro Ashihara, Isao Nishizono, Hidetaka Minakawa, Masahisa Okada, Yasusuke Sakurabayashi, Fumio Watanabe, Shin ichi Wakana: Automatic immunological measuring system. Fujirebio, Sughrue Mion Zinn Macpeak and Seas, October 27, 1992: US05158895 (120 worldwide citation)

An automatic immunoassay apparatus utilizes cartridges each having at least two wells, a first well containing solid phase material carrying antigen or antibody, and a second well containing antibody or antigen labelled with labelling compound. The wells may be sealed with a suitable sealing film be ...


2
Uchida Yoshiaki, Kurano Yoshihiro: Anti-apo-b-48 monoclonal antibody, hybridoma, and methods of use. Fujirebio, April 28, 1999: EP0911344-A1 (65 worldwide citation)

A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apoB-100.


3
Kobayashi Nobuo C O Fujirebio, Nakayama Yukihide C O Fujirebi, Kojima Kazuhiro C O Fujirebio, Yamaura Tetsuaki C O Fujirebio, Ikawa Hiroshi C O Fujirebio In: Hydantoin derivative as metalloprotease inhibitor.. Fujirebio, March 1, 1995: EP0640594-A1 (48 worldwide citation)

A hydantoin derivative represented by formula (I): wherein the all symbols are defined in the disclosure. The hydantoin derivative has an inhibitory activity on metalloprotease and hence is useful as analgesic and cardiovascular drug.


4
Ashihara Yoshihiro, Kasahara Yasushi: Method of measuring polynucleotide and reagent kit for use therein.. Fujirebio, May 22, 1985: EP0142299-A2 (44 worldwide citation)

Disclosed is a method of measuring a polynucleotide such as DNA and RNA in a body fluid which does not require immobilisation of the test sample and whereby the polynucleotide is easily determined, wherein an immobilised singlestranded polynucleotide which is labeled is hybridised with the single-st ...


5
Ikawa Hiroshi, Matsumoto Hajime, Kobayashi Nobuo, Kusunoki Jun: Pantothenic acid derivatives.. Fujirebio, April 10, 1991: EP0421441-A2 (44 worldwide citation)

Compounds represented by general formula (I) below wherein R and R, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group; R represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5 SIMILAR C25-aliphatic hydrocarbon group w ...


6
Hiroshi Ikawa, Hajime Matsumoto, Nobuo Kobayashi, Jun Kusunoki: Pantothenic acid derivatives. Fujirebio, Wenderoth Lind & Ponack, June 9, 1992: US05120738 (44 worldwide citation)

Compounds represented by general formula (I) below ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group;


7
Hosoda Akihiko, Nakayama Yukihide, Shibata Masahiro, Sekine Yasuo, Inaba Niro, Ikawa Hiroshi, Yamaura Tetsuaki, Tanabe Naoko: Aldehyde derivatives and their use as calpain inhibitors.. Fujirebio, December 30, 1992: EP0520336-A2 (43 worldwide citation)

Aldehyde derivatives with a specific calpain inhibiting activity and a platelet-aggregation inhibiting effect with formula (I) or formula (II): wherein R represents an aromatic hydrocarbon group, a heterocyclic group, or a group of -X-R in which X represents O, -S(O)m- (m = 0, 1, or 2), and R repres ...


8
Masahisa Okada, Yoshihiro Ashihara, Akira Yano, Masao Oishi, Katsuaki Yoshioka, Toshiomi Nakamura: Immunoassay using magnetic particle. Fujirebio, Nippon Paint, Jordan and Hamburg, June 14, 1994: US05320944 (33 worldwide citation)

An immunoassay method using magnetic particles comprising a core and a coating layer on the surface thereof, The core comprises an organic polymer and the coating layer comprises an iron oxide type ferrite coating layer. An antigen or an antibody is bound onto the surface of the coating layer and th ...


9
Yoshihiro Kinoshita, Kazunori Soma, Tomoo Saito: Method and apparatus for agglutination immunoassay. Fujirebio, Oblon Spivak McClelland Maier & Neustadt P C, October 6, 1998: US05817526 (33 worldwide citation)

An agglutination immunoassay method and apparatus therefor in which there are conducted the steps of contacting, in a container, a test sample suspected of containing a desired analyte and a reagent comprising sensitized magnetic-material containing particles capable of reacting with and binding to ...


10
Motohiro Sasaki, Masahiko Matsukawa, Katsuaki Yoshioka, Makoto Anan, Mitsuo Isomura, Yoshihiro Ashihara, Masahisa Okada: Magnetic particle and immunoassay using the same. Nippon Paint, Fujirebio, Jordan and Hamburg, April 7, 1998: US05736349 (32 worldwide citation)

There are disclosed a magnetic particle for an immunoassay method, which comprises a core and a coating layer formed on the surface of the core wherein said core comprises an organic polymer matrix and said coating layer comprises a mixed crystal ferrite represented by the formula: