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Inaba Takashi, Haas Julia, Shiozaki Makoto, Littman Nicole M, Yasue Katsutaka, Andrews Steven W, Sakai Atushi, Fryer Andrew M, Matsuo Takafumi, Laird Ellen R, Suma Akira, Shinozaki Yuichi, Hori Yoshikazu, Imai Hiroto, Negoro Tamotsu: Cyclopropane compounds and pharmaceutical use thereof. Japan Tobacco, Inaba Takashi, Haas Julia, Shiozaki Makoto, Littman Nicole M, Yasue Katsutaka, Andrews Steven W, Sakai Atushi, Fryer Andrew M, Matsuo Takafumi, Laird Ellen R, Suma Akira, Shinozaki Yuichi, Hori Yoshikazu, Imai Hiroto, Negoro Tamotsu, GARRETT Arthur S, June 30, 2005: WO/2005/058884 (26 worldwide citation)

The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is - (CH2) m-X- (CH2)n-A1 et ...


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Fryer Andrew M, Shiozaki Makoto, Littmann Nicole M, Inaba Takashi, Andrews Steven W, Yasue Katsutaka, Laird Ellen R, Yokota Masahiro, Haas Julia, Imai Hiroto, Maeda Katsuya, Shinozaki Yuichi, Hori Yoshikazu: N-substituted-n-sulfonylaminocyclopropane compounds and pharmaceutical use thereof. Japan Tobacco, Fryer Andrew M, Shiozaki Makoto, Littmann Nicole M, Inaba Takashi, Andrews Steven W, Yasue Katsutaka, Laird Ellen R, Yokota Masahiro, Haas Julia, Imai Hiroto, Maeda Katsuya, Shinozaki Yuichi, Hori Yoshikazu, GARRETT Arthur S, June 30, 2005: WO/2005/058808 (21 worldwide citation)

The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1) : wherein R ...


4
Fryer Andrew M: Mmp inhibitors and methods of use thereof. Array Biopharma, Fryer Andrew M, HARRIS Robert J, December 4, 2008: WO/2008/147763

Provided are MMP inhibitors having the Formula (I): wherein R1, R2 and Y are as defined herein, which are useful in the treatment and/or prevention of MMP-mediated diseases and disorders.


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Fryer Andrew M: Mmp inhibitors and methods of use thereof. Array Biopharma, Fryer Andrew M, HARRIS Robert J, December 4, 2008: WO/2008/147764

Provided are MMP inhibitors having the Formula (I): wherein R1, R2 and Y are as defined herein, which are useful in the treatment and/or prevention of MMP-mediated diseases and disorders.