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George Dawn M, Dixon Richard W, Friedman Michael, Hobson Adrian, Li Biqin, Wang Lu, Wu Xiaoyun, Wishart Neil: Aminopyrrolidines as chemokine receptor antagonists. Abbott Laboratories, George Dawn M, Dixon Richard W, Friedman Michael, Hobson Adrian, Li Biqin, Wang Lu, Wu Xiaoyun, Wishart Neil, O BRIEN Gayle, May 22, 2008: WO/2008/060621 (7 worldwide citation)

The present invention is directed to novel aminopyrrolidines of formula (I), pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine ...


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Rubinstein Abraham, Radai Raphael, Friedman Michael, Tirosh Boaz, Baluom Muhammad, Nassar Taher: Controlled release oral drug delivery system. Yissum Research Development Company Of The Hebrew University Of Jerusalem, Rubinstein Abraham, Radai Raphael, Friedman Michael, Tirosh Boaz, Baluom Muhammad, Nassar Taher, BROOK David E, December 21, 1995: WO/1995/034294 (5 worldwide citation)

The present invention relates to a controlled release drug delivery system comprising a drug which is susceptible to enzymatic degradation by enzymes present in the intestinal tract; and a polymeric matrix which undergoes erosion in the gastrointestinal tract comprising a hydrogel-forming polymer se ...


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Hirst Gavin C, Calderwood David, Wishart Neil, Rafferty Paul, Ritter Kurt, Arnold Lee D, Friedman Michael M: Pyrazolopyrimidines as therapeutic agents. Basf Aktiengesellschaft, Hirst Gavin C, Calderwood David, Wishart Neil, Rafferty Paul, Ritter Kurt, Arnold Lee D, Friedman Michael M, DECONTI Giulio A, March 22, 2001: WO/2001/019829 (2 worldwide citation)

The present invention provides compounds of Formula (I), including pharmaceutically acceptable salts and/or prodrugs thereof, where G, R¿a?, R¿2?, R¿3? are defined as described herein and their use as protein Kinase inhibitors.


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Friedman Michael, Levin Orna, Forman Yochanan, Friedman Doron: Effervescent granules. Farmo Nat, Friedman Michael, Levin Orna, Forman Yochanan, Friedman Doron, Friedman Mark M, FRIEDMAN Mark M, May 14, 1999: WO/1999/022718 (2 worldwide citation)

An effervescent granule for the release and efficient dispersion of a herbal preparation in water. Also provided is a method of making the herbal medication granule and a method of using the granule. The granule of the present invention is particularly efficient for the dispersion of a herbal prepar ...


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Afargan Michel, Kirmayer David, Lapidot Noa, Friedman Michael, Hoffman Amnon: Gastro-retentive diagnostic assemblies. Intec Pharma, Yissum Research Development Company, Afargan Michel, Kirmayer David, Lapidot Noa, Friedman Michael, Hoffman Amnon, REINHOLD COHN AND PARTNERS, July 13, 2006: WO/2006/072948 (2 worldwide citation)

The present invention provides a gastro-retentive diagnostic assembly (GRDA) for use in determining a condition of a subject's gastrointestinal tract (GI tract), comprising a folded single or multi-layered device comprising a diagnostic utility, such as a contrasting agent, the device prior to foldi ...


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Hirst Gavin C, Rafferty Paul, Ritter Kurt, Calderwood David, Wishart Neil, Arnold Lee D, Friedman Michael M: Pyrazolopyrimidines as therapeutic agents. Abbott & Co Kg, Hirst Gavin C, Rafferty Paul, Ritter Kurt, Calderwood David, Wishart Neil, Arnold Lee D, Friedman Michael M, CONWAY John D, October 3, 2002: WO/2002/076986 (1 worldwide citation)

The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, and R3 are defined as described herein.