1
Laurence A Roth, Stephen Jack Herman: Targeted delivery via biodegradable polymers. Focal, Arnall Golden & Gregory, March 9, 1999: US05879713 (430 worldwide citation)

Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle such as lipos ...


2
Amapreet S Sawhney, Michelle D Lyman, Peter K Jarrett, Ronald S Rudowsky: Compliant tissue sealants. Focal, Arnall Golden & Gregory, May 4, 1999: US05900245 (252 worldwide citation)

An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue ...


3
Carl W Hennige, Edward C Driscoll Jr: Probe for medical imaging and therapy using ultrasound. Focal Surgery, Blakely Sokoloff Taylor & Zafman, February 20, 1996: US05492126 (221 worldwide citation)

A probe for inspecting and treating an internal organ of a patient. The probe includes a tube having a proximal end and a distal end. The tube has a flexible portion near the distal end. A head is coupled to the flexible portion at the distal end of the tube. The head includes a HIFU transducer. The ...


4
Richard D Leavitt, Luis Z Avila: Method of local radiotherapy by polymerizing a material in vivo to form a hydrogel. Focal, Arnall Golden & Gregory, August 24, 1999: US05942209 (216 worldwide citation)

Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physic ...


5
Amapreet S Sawhney, Michelle D Lyman, Peter K Jarrett, Ronald S Rudowsky: Compliant tissue sealants. Focal, Arnall Golden & Gregory, April 17, 2001: US06217894 (211 worldwide citation)

An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue ...


6
James W Snow, Graham A J Smith, Geoffrey H Channer, John W Purdy: Fibre optic single mode rotary joint. Focal Technologies Incorporated, Jones Tullar & Cooper, August 13, 1991: US05039193 (185 worldwide citation)

The invention is a rotary joint for singlemode optical fibers, having a fixed and a rotating part to permit the transmission of optical signals across a rotational interface (such as a winch or turret) with minimal insertion loss and, in particular, low reflections (good return loss). There is no ne ...


7
Arthur J Coury, Amarpreet S Sawhney, Jeffrey A Hubbell, C Michael Philbrook: Hemostatic tissue sealants. Focal, Arnall Golden & Gregory, December 19, 2000: US06162241 (170 worldwide citation)

A method of controlling hemostasis by applying a hemostatic agent in a tissue sealant composition. The tissue sealant is a biodegradable, biocompatible synthetic polymer that may not intrinsically possess strong hemostatic properties. Inclusion of a hemostatic material in the tissue sealant can cont ...


8
Chandrashekhar P Pathak, Shikha P Barman, C Michael Philbrook, Amarpreet S Sawhney, Arthur J Coury, Luis Z Avila, Mark T Kieras: Multiblock biodegradable hydrogels for drug delivery and tissue treatment. Focal, Arnall Golden & Gregory, March 13, 2001: US06201065 (140 worldwide citation)

Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed fro ...


9
Chandrashekhar P Pathak, Amarpreet S Sawhney, Jeffrey A Hubbell, Stephen J Herman, Laurence A Roth, Patrick K Campbell, Kevin M Berrigan, Peter K Jarrett, Arthur J Coury: Apparatus for intraluminal photothermoforming. Focal, Wolf Greenfield & Sacks P C, September 2, 1997: US05662712 (119 worldwide citation)

A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed ...


10
Laurence A Roth, Stephen J Herman, Farhad Khosravi, David Melanson, Michael Dumont, Patrick K Campbell, John C Spiridigliozzi: Devices and methods for application of intraluminal photopolymerized gels. Focal, Wolf Greenfield & Sacks P C, July 14, 1998: US05779673 (111 worldwide citation)

Devices for providing polymeric layers on the interior surface of body lumens and spaces are disclosed. The devices can include proximal and distal occlusion elements to define the treatment space and an optical emitter to provide light for a photopolymerization procedure. The devices may include a ...