1
Pierre Autant, Jean Philippe Selles, Gerard Soula: Medicinal and/or nutritional microcapsules for oral administration. Flamel Technologies, Bacon & Thomas, February 8, 2000: US06022562 (61 worldwide citation)

The present invention relates to microcapsules for the oral administration of medicinal and/or nutritional active principles (AP), which are smaller than or equal to 1000 .mu.m in size. These microcapsules consist of particles which are coated with a coating material consisting of a mixture of a fil ...


2
Sylvain Huille, Alain Lemercier, Gerard Soula: Particles based on polyamino acid(s) and capable of being used as delivery vehicles for active principle(s) and method for preparing them. Flamel Technologies, Bacon & Thomas, May 18, 1999: US05904936 (38 worldwide citation)

The present invention relates to delivery vehicles which are useful for the administration of active principles (APs), preferably medicinal or nutritional active principles, in particular via the oral or parenteral route.


3
Christian Gagnieu: Crosslinkable collagen derivatives, process for their production and their application to the preparation of biomaterials. Flamel Technologies, Bacon & Thomas, May 2, 1995: US05412076 (32 worldwide citation)

The present invention relates to a crosslinkable modified collagen which is soluble in water and/or in aprotic polar organic solvents and which contains free or substituted thiol groups carried by residues of cysteine or derivatives thereof, at least some of the residues being fixed to the collagen ...


4
Sylvain Huille, Florence Nicolas, Nathan Brison, Gérard Soula: Particles based on polyamino-acid(s) and methods for preparing same. Flamel Technologies, James C Lydon, October 7, 2003: US06630171 (26 worldwide citation)

The invention concerns delivery particles (DP's) for active principles (AP's) based on linear amphiphilic polyamino-acids (PAA's), with &agr;-peptide chains, capable of being spontaneously formed by contacting PAA's with a liquid medium, preferably with water, wherein the hydroph ...


5
Alain Lemercier, R acute over, Sylvain Huille, G acute over: Composite gel microparticles as active principle carriers. Flamel Technologies, Dennison Scheiner Schultz & Wakeman, January 30, 2001: US06180141 (24 worldwide citation)

The invention relates to vectors for delivering medicinal, nutritional, plant-protection or cosmetic active principles, these delivery particles being of small, controllable and adjustable particle size, which protect the active principle, and being biocompatible, biodegradable, non-immunogenic, sta ...


6
Catherine Castan, Florence Guimberteau, Rémi Meyrueix: Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s). Flamel Technologies, Patton Boggs, March 15, 2011: US07906145 (20 worldwide citation)

The invention concerns liquid pharmaceutical formulations, for oral delivery, with modified release of active principle(s) excluding amoxicillin and consisting of suspensions of coated particles of active principles (microcapsules). The microcapsules constituting the dispersed phase of the suspensio ...


7
Florence Guimberteau, Frederic Dargelas: Anti-misuse microparticulate oral pharmaceutical form. Flamel Technologies, Patton Boggs, May 21, 2013: US08445023 (19 worldwide citation)

The present invention relates to solid microparticulate oral pharmaceutical forms whose composition and structure make it possible to avoid misuse of the pharmaceutical active principle (AP) they contain. The object of the present invention is to prevent solid oral drugs from being misappropriated f ...


8
Florence Guimberteau, Frédéric Dargelas: Anti-misuse microparticulate oral pharmaceutical form. Flamel Technologies, Patton Boggs, February 18, 2014: US08652529 (18 worldwide citation)

The present invention relates to solid microparticulate oral pharmaceutical forms whose composition and structure make it possible to avoid misuse of the pharmaceutical active principle they contain. The invention relates to a solid oral pharmaceutical form which is characterized in that it contains ...


9
Guimberteau Florence, Meyrueix Rémi, Soula Gérard: (Fr) Forme medicamenteuse orale microparticulaire anti-mesusage, (En) Anti-misuse microparticulate oral drug form. Flamel Technologies, Guimberteau Florence, Meyrueix Rémi, Soula Gérard, COGNIAT Eric, August 31, 2006: WO/2006/089843 (18 worldwide citation)

(EN) The invention relates to solid microparticulate oral dosage forms having a composition that prevents the misuse of the active pharmaceutical ingredient (API) contained therein. The aim of the invention is to prevent the improper use of solid oral drugs for any use other than the therapeutic use ...


10
Valérie Legrand, Catherine Castan, Rémi Meyrueix, Gérard Soula: Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles. Flamel Technologies, Patton Boggs, January 24, 2012: US08101209 (16 worldwide citation)

The invention relates to a microparticulate system for the delayed and controlled release of active principles (AP) whose absorption window in vivo is essentially limited to the upper parts of the gastrointestinal tract, this system being intended for oral administration. The object of the invention ...