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BUNDA Jaime L, COX Christopher D, DUDKIN Vadim Y, FIJI Hannah D, KELLY Michael J III, LAYTON Mark E, PERO Joseph E, SHIPE William D, STEEN Justin T: COMPOSÉS DISOINDOLINONE UTILES COMME INHIBITEURS DE PDE 10, ISOINDOLINONE PDE10 INHIBITORS. MERCK SHARP & DOHME, BUNDA Jaime L, COX Christopher D, DUDKIN Vadim Y, FIJI Hannah D, KELLY Michael J III, LAYTON Mark E, PERO Joseph E, SHIPE William D, STEEN Justin T, May 3, 2012: WO/2012/058133 (6 worldwide citation)

The present invention is directed to isoindolinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychi ...


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FIJI Hannah D, KELLY Michael J III, KERN Jeffrey C, LAYTON Mark E, PERO Joseph E, REIF Alexander J, ROSSI Michael A: DÉRIVÉS DIMIDAZOPYRIDIN-2-ONE, IMIDAZOPYRIDIN-2-ONE DERIVATIVES. MERCK SHARP & DOHME, FIJI Hannah D, KELLY Michael J III, KERN Jeffrey C, LAYTON Mark E, PERO Joseph E, REIF Alexander J, ROSSI Michael A, December 20, 2012: WO/2012/174199 (1 worldwide citation)

The present invention is directed to imidazopyridin-2-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and ...



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