1
Francesco Della Valle, Gabriella Calderini, Alessandro Rastrelli, Aurelio Romeo: Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts. Fidia S p A, Birch Stewart Kolasch & Birch, July 5, 1994: US05326356 (217 worldwide citation)

It is provided biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500.mu., characterised by containing an ordered series of holes of a constant size between 10 and 1000.mu., separated from each other by a constant ...


2
Francesco della Valle, Aurelio Romeo: Esters of hyaluronic acid. Fidia S p A, Birch Stewart Kolasch & Birch, July 25, 1989: US04851521 (183 worldwide citation)

The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterfied, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases.


3
Francesco della Valle, Aurelio Romeo: Cross-linked esters of hyaluronic acid. Fidia S p A, Birch Stewart Kolasch & Birch, September 18, 1990: US04957744 (141 worldwide citation)

Cross-linked esters of hyaluronic acid are provided which result from the esterification of polyhydric alcohols with two or more carboxy groups of the hyaluronic acid polysaccharide. These cross-linked esters are useful in the field of biodegradable plastics for sanitary and surgical articles and in ...


4
Francesco della Valle, Aurelio Romeo, Silvana Lorenzi: Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same. Fidia S p A, Birch Stewart Kolasch & Birch, November 24, 1992: US05166331 (108 worldwide citation)

Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intr ...


5
Francesco della Valle, Aurelio Romeo: Polysaccharide esters and their salts. Fidia S p A, Birch Stewart Kolasch & Birch, October 23, 1990: US04965353 (90 worldwide citation)

The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterified, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases.


6
Francesco Della Valle, Aurelio Romeo: Crosslinked carboxy polysaccharides. Fidia S p A, Birch Stewart Kolasch & Birch, October 14, 1997: US05676964 (89 worldwide citation)

Inter and/or intramolecular cross-linked esters of acid polysaccharides are disclosed in which a part or all of the carboxy groups are esterified with hydroxyl groups of the same molecule and/or of different molecules of the acid polysaccharide. These inner cross-linked esters of polysaccharide acid ...


7
Francesco della Valle, Aurelio Romeo, Silvana Lorenzi: Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions. Fidia S p A, Birch Stewart Kolasch & Birch, August 15, 1995: US05442053 (83 worldwide citation)

Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intr ...


8
Francesco Della Valle, Aurelio Romeo, Silvana Lorenzi: Process for preparing salt of hyaluronic acid with a pharmaceutically active substance. Fidia S p A, Birch Stewart Kolasch & Birch, April 5, 1988: US04736024 (77 worldwide citation)

Pharmaceutical preparations for topical administration containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, alu ...


9
Aurelio Romeo, Bruno Silvestrini, Gunter Kirschner: Pharmaceutical preparations comprised of salts of hyaluronic acid with local anaesthetics. Fidia S p A, Leonard R Svensson, Birch Stewart Kolasch & Birch, May 1, 2001: US06224857 (70 worldwide citation)

Pharmaceutical preparations are described, comprised of salts of hyaluronic acid with a basic anesthetic containing aliphatics and/or amino groups, particularly salts with benzydamine or bupivacaine.


10
Francesco della Valle, Aurelio Romeo: Partial esters of hyaluronic acid. Fidia S p A, Birch Stewart Kolasch & Birch, April 13, 1993: US05202431 (46 worldwide citation)

The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterified, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases. The compounds possess interesting and precious bioplastic and p ...



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