1
Benjamin Oshlack, Mark Chasin, Frank Pedi Jr: Controlled release formulations coated with aqueous dispersions of acrylic polymers. Euro Celtique, Steinberg Raskin & Davidson P C, June 17, 1997: US05639476 (605 worldwide citation)

A stable solid controlled release formulation having a coating derived from an aqueous dispersion of a hydrophobic acrylic polymer includes a substrate including an active agent selected from the group consisting of a systemically active therapeutic agent, a locally active therapeutic agent, a disin ...


2
Benjamin Oshlack, Mark Chasin, John J Minogue, Robert F Kaiko: Controlled release oxycodone compositions. Euro Celtique, Steinberg Raskin & Davidson P C, August 27, 1996: US05549912 (264 worldwide citation)

A method for substantially reducing the range in daily dosages required to control pain in approximately 90% of patients is disclosed whereby an oral solid controlled release dosage formulation having from about 10 to about 40 mg of oxycodone or a salt thereof is administered to a patient. The formu ...


3
Benjamin Oshlack, Mark Chasin, John Joseph Minogue, Robert Francis Kaiko: Controlled release oxycodone compositions. Euro Celtique, Steinberg Raskin & Davidson P C, August 12, 1997: US05656295 (252 worldwide citation)

A method for substantially reducing the range in daily dosages required to control pain in approximately 90% of patients is disclosed whereby an oral solid controlled release dosage formulation having from about 10 to about 40 mg of oxycodone or a salt thereof is administered to a patient. The formu ...


4
Benjamin Oshlack, Mark Chasin, Hua Pin Huang: Extruded orally administrable opioid formulations. Euro Celtique, Davidson Davidson & Kappel, September 28, 1999: US05958452 (249 worldwide citation)

Bioavailable sustained release oral opioid analgesic dosage forms, comprising a plurality of multiparticulates produced via melt extrusion techniques are disclosed.


5
Philip J Palermo, Robert D Colucci, Robert F Kaiko: Method of preventing abuse of opioid dosage forms. Euro Celtique, Davidson Davidson & Kappel, May 8, 2001: US06228863 (236 worldwide citation)

The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step ...


6
Robert F Kaiko, Robert D Colucci: Opioid agonist/opioid antagonist/acetaminophen combinations. Euro Celtique, Davidson Davidson & Kappel, April 23, 2002: US06375957 (233 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an opioid agonist, acetaminophen and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the ...


7
Benjamin Oshlack, Frank Pedi Jr, Mark Chasin: Controlled release formulations coated with aqueous dispersions of acrylic polymers. Euro Celtique, Steinberg Raskin & Davidson P C, December 3, 1996: US05580578 (227 worldwide citation)

A stable solid controlled release formulation having a coating derived from an aqueous dispersion of a hydrophobic acrylic polymer includes a substrate including an active agent selected from the group consisting of a systemically active therapeutic agent, a locally active therapeutic agent, a disin ...


8
Benjamin Oshlack, Mark Chasin, Hua Pin Huang: Extruded multi-particulates. Euro Celtique, Davidson Davidson & Kappel, October 12, 1999: US05965161 (220 worldwide citation)

A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm a ...


9
Benjamin Oshlack, Mark Chasin: Immediate release tablet cores of insoluble drugs having sustained-release coating. Euro Celtique, Steinberg Raskin & Davidson, March 19, 1996: US05500227 (194 worldwide citation)

A controlled release tablet for oral administration is disclosed which has a tablet core including an insoluble therapeutically active agent having an aqueous solubility of less than or equal to about 5 mg/ml in a sufficient amount to render a therapeutic effect. The core provides rapid release of s ...


10
Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Treavor John Knott, Joanne Heafield, Deborah Challis: Method of preparing sustained release pharmaceutical compositions. Euro Celtique, Clifford M Davidson, December 15, 1998: US05849240 (188 worldwide citation)

A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanic ...