1
Massimo Calanchi, Marco Zema, Gabriele Brunetti, Enzo Giorgetti: Method for targeted and controlled release of drugs in the intestinal tract and more particularly in the colon. Eurand International S p A, May 4, 1999: US05900252 (109 worldwide citation)

The object of the present invention is to obtain a targeted and controlled release of drugs, the pharmacological action and absorption of which takes place in the intestine and in particular in the ileum and in the colon.


2
Marco Zema, Luigi G Mapelli, Marco G Marconi: Pharmaceutical composition for rapid suspension in water. Eurand International S p A, Adley F Mandel, April 26, 1994: US05306506 (46 worldwide citation)

The invention provides a solid pharmaceutical composition for addition to water to produce a suspension of a drug comprising (a) a drug which is substantially water-insoluble or microencapsulated; (b) a thickening or suspending agent; (c) a pharmaceutically acceptable acid; (d) a pharmaceutically ac ...


3
Luca Dobetti: Fast disintegrating tablets. Eurand International S p A, Thompson Hine, July 22, 2003: US06596311 (39 worldwide citation)

This invention provides a formulation for preparing a fast disintegrating tablet comprising a drug in multiparticulate form, one or more water insoluble inorganic excipients, one or more disintegrants, and optionally one or more substantially water soluble excipients, the amounts of said ingredients ...


4
Massimo Maria Calanchi, Marco Giuseppe Raffaele Marconi, Luigi Giovanni Mapelli: Pharmaceutical composition for rapid suspension in aqueous media. Eurand International S p A, Thompson Hine, July 17, 2001: US06261602 (32 worldwide citation)

The invention provides a granular product useful as a pharmaceutical carrier which can be used for the preparation of pharmaceutical compositions that are capable of rapid suspension in water or aqueous media including saliva. The compositions may be used by addition to a glass of water with stirrin ...


5
Pierandrea Esposito, Nicoletta Coceani, Maria Dorly Del Curto, Fabio Carli: Biphasic multicomponent pharmaceutical dosage forms containing substances able to modify the partitioning of drugs. Eurand International S p A, Thompson Hine, December 17, 2002: US06495160 (28 worldwide citation)

The invention provides a biphasic multicomponent pharmaceutical composition consisting of an oil phase and a water phase, comprising one or more lipophilic or oil carrier, one or more hydrophilic or aqueous carrier, one or more ionic or nonionic type surfactant, one or more cosurfactant, one or more ...


6
Matteo Ghirri, Marco Zema: Oral calcitonin pharmaceutical compositions and methods of making the same. Eurand International S p A, Thompson Hine, March 5, 2002: US06352974 (16 worldwide citation)

The present invention relates to novel compositions, in particular to compositions comprising calcitonin or a fragment or conjugate thereof and to methods for preparing such compositions. It also relates to oral formulations comprising the compositions and to shelf stable formulations of calcitonin ...


7
Massimo Maria Calanchi, Stefano De Luigi Bruschi, Leonardo Gentilini, Luigi Giovanni Mapelli: Wettable microcapsules having hydrophobic polymer coated cores. Eurand International S p A, Thompson Hine, January 21, 2003: US06509034 (12 worldwide citation)

This invention concerns wettable microcapsules ethylcellulose coated cores and to processes for their preparation; in particular, to microcapsules with ethylcellulose coats that are wettable so that they are suspendable in aqueous medium. The wettable microcapsules can be prepared by applying ethylc ...


8
Livio Maria Cornelli, Giovanni La Grasta, Marco Giuseppe Raffaele Marconi: Layering process for multiparticulate dosage form. Eurand International S p A, Thompson Hine, May 27, 2003: US06569462 (11 worldwide citation)

The present invention relates to a new layering process, in particular to a process for the manufacture of multiparticulate solid oral dosage forms based on a dry spray layering technique optionally with electrostatic attraction. The invention also relates to an apparatus for use in the process.


9
Carla Marcella Caramella, Maria Cristina Bonferoni: Complex between carrageenan and a water soluble drug having a specific granulometry and relative controlled release pharamaceutical compositions. Eurand International S p A, Thompson Hine, March 12, 2002: US06355272 (6 worldwide citation)

A complex between carrageenan and a water soluble drug characterized in powder form having an average particle size comprised between 10 and 100 &mgr;m, and the basic water drug is contained in the complex in amounts ranging from 1.5 and 5 mmol/g carrageenan, a process for preparing this complex and ...


10
Fabio Carli, Massimo Bresciani, Tiziana Canal, Paolo Gambini: Pharmaceutical compositions in form of polymeric microparticles obtained by extrusion and spheronization. Eurand International S p A, Thompson Hine, March 12, 2002: US06355273 (4 worldwide citation)

Process for the preparation of pharmaceutical compositions comprising one or more polymers and one or more drugs by the extrusion and spheronization technique, wherein polymers belong to the group of the cross-linked amphiphilic polymers.