1
Martin E Schwab, Pierenrico W Caroni, Paolo A Paganetti: Diagnostic methods using neurite growth regulatory factors. Erziehungsdirektion of the Canton Zurich, Pennie & Edmonds, October 5, 1993: US05250414 (44 worldwide citation)

The proteins of the present invention include central nervous system myelin associated proteins and metalloproteases associated with glioblastoma cells and other malignant tumors which can metastasize to the brain. The CNS myelin associated proteins inhibit neurite outgrowth in nerve cells and neuro ...


2
Martin E Schwab, Pierenrico W Caroni: Neurite growth regulatory factors, antibodies thereto, and pharmaceutical compositions. Erziehungsdirektion of the Canton Zurich, Pennie & Edmonds, November 4, 1997: US05684133 (15 worldwide citation)

The CNS myelin associated proteins inhibit neurite outgrowth in nerve cells and neuroblastoma cells, and can also inhibit fibroblast spreading. Such inhibitory proteins include a 35,000 dalton and a 250,000 dalton molecular weight protein and analogs, derivatives, and fragments thereof. The CNS myel ...


3
Martin E Schwab, Pierenrico W Caroni, Paolo A Paganetti: Treatment of CNS tumors with metalloprotease inhibitors. Erziehungsdirektion of the Canton Zurich, Pennie & Edmonds, February 15, 2000: US06025333 (6 worldwide citation)

The present invention relates to genes and their encoded proteins which regulate neurite growth and the diagnostic and therapeutic use of such proteins (termed herein neurite growth regulatory factors). The proteins of the present invention include central nervous system myelin associated proteins a ...


4
Martin E Schwab, Pierenrico W Caroni, Paolo A Paganetti: Neurite growth regulatory factors. Erziehungsdirektion of the Canton Zurich, Pennie & Edmonds, August 15, 2000: US06103232 (2 worldwide citation)

The present invention relates to methods of inducing neurite outgrowth in the central nervous system by antagonizing neural growth inhibitory factors. More particularly, the present invention is directed to use of antibodies to the central nervous system (CNS) myelin associated proteins; such antibo ...


5
Schwab Martin E, Caroni Pierenrico W, Paganetti Paolo A: Facteurs de regulations de la croissance des axones, Neurite growth regulatory factors. Schwab Martin E, Caroni Pierenrico W, Paganetti Paolo A, Erziehungsdirektion Of The Canton Zurich, OSLER HOSKIN & HARCOURT, July 11, 2000: CA1341050

The present invention relates to genes andtheir encoded proteins which regulate neurite growth andthe diagnostic and therapeutic use of such proteins(termed herein neurite growth regulatory factors). Theproteins of the present invention include central nervous system myelin associated proteins and m ...


6
Schwab Martin E, Caroni Pierenrico W, Paganetti Paolo A: Neurite growth regulatory factors. Erziehungsdirektion Of The Canton Zurich, KIRKER Gaylord E, May 17, 1990: WO/1990/005191

The present invention relates to the therapeutic and diagnostic use of genes and their encoded proteins (termed herein neurite growth regulatory factors). The proteins of the present invention include metalloproteases associated with glioblastoma cells and other malignant tumors which can metastasiz ...


7
Schwab Martin E, Schnell Lisa: A combination of neurotrophin and antibody directed toward myelin-associated neurite growth inhibitory protein promotes central nervous system regeneration. Erziehungsdirektion Of The Canton Zurich, KIRKER 122 rue de Genève PO Box 65 CH 1226 Thônex, August 18, 1994: WO/1994/017831

The present invention relates to methods of promoting central nervous system regeneration in a subject in need of such treatment comprising administering a therapeutically effective amount of an essentially purified and isolated neurotrophin family member together with an antibody directed toward a ...


8
Schwab Martin E, Caroni Pierenrico W, Paganetti Paolo A: Neurite growth regulatory factors. Erziehungsdirektion Of The Canton Zurich, KIRKER PO Box 1736 Rue du Mont Blanc 14 CH 1211 Genève 1, January 7, 1993: WO/1993/000427

The present invention relates to genes and their encoded proteins which regulate neurite growth and the diagnostic and therapeutic use of such proteins (termed herein neurite growth regulatory factors). The proteins of the present invention include central nervous system myelin associated proteins a ...