1
Anthony Martinez, Richard B Greenwald: Non-antigenic branched polymer conjugates. Enzon, Michael N Mercanti, July 1, 1997: US05643575 (413 worldwide citation)

Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologically active material are used as attachment site ...


2
Shmuel Zalipsky: Active carbonates of polyalkylene oxides for modification of polypeptides. Enzon, John P White, Craig J Arnold, June 16, 1992: US05122614 (375 worldwide citation)

Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted ...


3
Robert C Ladner, Robert E Bird, Karl Hardman: Single polypeptide chain binding molecules. Enzon, Jorge A Goldstein, November 9, 1993: US05260203 (243 worldwide citation)

The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombina ...


4
Samuel Zalipsky, Durgadas Bolikal, Aruna Nathan, Joachim B Kohn: Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon. Enzon, Lerner David Littenberg Krumholz & Mentlik, June 15, 1993: US05219564 (235 worldwide citation)

Copolymers of poly(alkylene oxides) and amino acids or peptide sequences are disclosed, which amino acids or peptide sequences have pendant functional groups that are capable of being conjugated with pharmaceutically active compounds for drug delivery systems and cross-linked to form polymer matrice ...


5
Shmuel Zalipsky: Active carbonates of polyalkylene oxides for modification of polypeptides. Enzon, Michael N Mercanti, March 18, 1997: US05612460 (214 worldwide citation)

Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted ...


6
Richard B Greenwald, Anthony J Martinez: Water-soluble non-antigenic polymer linkable to biologically active material. Enzon, Roberts & Mercanti, September 5, 2000: US06113906 (204 worldwide citation)

Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologically active material are used as attachment site ...


7
Shmuel Zalipsky: Active carbonates of polyalkylene oxides for modification of polypeptides. Enzon, Michael N Mercanti, June 28, 1994: US05324844 (172 worldwide citation)

Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted ...


8
Richard B Greenwald, Anthony J Martinez: Non-antigenic branched polymer conjugates. Enzon, Roberts & Mercanti, July 6, 1999: US05919455 (151 worldwide citation)

Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologically active material are used as attachment site ...


9
Richard B Greenwald, Annapurna Pendri: High molecular weight polymer-based prodrugs. Enzon, Michael N Mercanti, March 25, 1997: US05614549 (150 worldwide citation)

Water-soluble prodrugs of the formula: ##STR1## wherein: D is a biologically active nucleophile;


10
Richard B Greenwald: Azlactone activated polyalkylene oxides conjugated to biologically active nucleophiles. Enzon, Michael N Mercanti, October 22, 1996: US05567422 (135 worldwide citation)

Water-soluble azlactone activated polyalkylene oxides having improved hydrolytic stability and conjugates of the azlactone activated polyalkylene oxides with biologically active nucleophiles are disclosed. Methods of forming and conjugating the activated polyalkylene oxides with biologically active ...