1
Amiot Bruce P: Cell culture apparatus.. Endotronics, March 17, 1993: EP0531631-A1 (88 worldwide citation)

A compact, easily assembled cell culturing device comprising at least one cell culturing envelope (1), the interior of which defines a cell culturing space. The cell culturing envelope is retained within a pair of rigid plates (80,80 min ) having various reliefs which, in turn, form cavities when th ...


2
Micheal L Gruenberg: Apparatus for delivering a controlled dosage of a chemical substance. Endotronics, Kinney & Lange, December 16, 1986: US04629686 (62 worldwide citation)

An apparatus is disclosed which delivers a dosage of a chemical substance preferably to a biological tissue in such a controlled manner that the concentration affecting the biological tissue is known at each and every point in time. The apparatus includes a plurality of vessels with each vessel cont ...


3
Ray F Cracauer, Robert D Walker, Micheal L Gruenberg: Hollow fiber cell culture device and method of operation. Endotronics, Kinney & Lange, February 14, 1989: US04804628 (58 worldwide citation)

An improved cell culturing device includes a hollow fiber cartridge having a shell and a plurality of capillaries extending through the shell with at least some of the capillaries having selectively permeable walls. A cell culturing space is located between the shell and capillaries. The improvement ...


4
Bruce P Amiot: Cell culture apparatus. Endotronics, Sughrue Mion Zinn Macpeak & Seas, January 7, 1992: US05079168 (58 worldwide citation)

A compact, easily assembled cell culturing device comprising at least one envelope, the interior of which defines a cell culturing space wherein the envelope is spirally wrapped about an elongated core and which provides for optimal gas delivery and removal to and from the cell culturing space which ...


5
William H Harm, John J Peluso: Culturing apparatus. Endotronics, Kinney & Lange, March 17, 1987: US04650766 (54 worldwide citation)

An apparatus for growing and maintaining microorganisms or cells within a culturing chamber simultaneously heats and gasses a nutrient solution being delivered through the culturing chamber. The apparatus includes a pump for pumping the nutrient solution from a nutrient source through gas-diffusable ...


6
Salstrom John S, Rohrbaugh Mark L, Thoma Hans A: Hepatitis b surface antigen formed by recombinant dna techniques, vaccines, diagnostics, cell lines and methods of forming same.. Endotronics, October 22, 1986: EP0198474-A1 (50 worldwide citation)

Bacterial plasmids carrying the PreS1-PreS2-S protein coding region, but lacking sequences encoding the hepatitis B core antigen, are used for transfection of eukaryotic cell lines for production of particles containing polypeptides encoded by the PreS1-PreS2-S protein coding region.


7
Bert R Bach: Method and apparatus for growing cells in vitro. Endotronics, Kinney & Lange, March 3, 1987: US04647539 (43 worldwide citation)

The present invention includes a cell culture apparatus for growing and maintaining living cells in vitro. The cell culture apparatus includes a shell being at least partially constructed of a flexible material. A plurality of capillaries are disposed within the shell, defining a cell culturing spac ...


8
Robert D Walker: Apparatus for administering a controlled dosage of a chemical substance having an improved culture chamber. Endotronics, Kinney & Lange, October 21, 1986: US04618586 (38 worldwide citation)

An apparatus delivers a dosage of a chemical stimuli or drug in such a controlled manner that the concentration at the point of delivery is known at each and every point in time. The apparatus includes a plurality of vessels with each vessel containing a different concentration of the drug or chemic ...


9
William H Harm, Mark D Hirschel, Michael L Gruenberg: Apparatus and method for culturing cells, removing waste and concentrating product. Endotronics, Kinney & Lange, February 2, 1988: US04722902 (38 worldwide citation)

An apparatus and method for culturing cells includes a waste removal and product concentrating loop in which waste is removed from the medium and product produced by the cells is concentrated for harvesting. The apparatus includes a reservoir for retaining a supply of medium. The reservoir is in flu ...


10
John R Wilson, William A Gaines Jr, Darrell P Page, William H Harm: Method of culturing cells using highly gas saturated media. Endotronics, Sughrue Mion Zinn Macpeak & Seas, November 27, 1990: US04973558 (30 worldwide citation)

A method of culturing cells by providing a highly gassed media on a continuous basis to cells grown in a hollow fiber cartridge includes entraining the media with gas above the gas solubility level of the media. The media is then permitted to rest in a substantially quiescent state so that non-solub ...