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Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Parker Matthew A, Howard Stephen J, Santhapuram Hari Krishna, Satyam Apparao, Reddy Joseph Anand: Vitamin receptor binding drug delivery conjugates. Endocyte, Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Parker Matthew A, Howard Stephen J, Santhapuram Hari Krishna, Satyam Apparao, Reddy Joseph Anand, BALL Rebecca L, August 19, 2004: WO/2004/069159 (52 worldwide citation)

The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety is a vitamin, or a vitamin receptor binding analog ...


2
Christopher P Leamon, Matthew A Parker: Vitamin-targeted imaging agents. Endocyte, Barnes & Thornburg, October 31, 2006: US07128893 (45 worldwide citation)

The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by using such a vitamin as the targeting ligand for the imaging agent. The invention provides a compound o ...


3
Iontcho R Vlahov, Christopher P Leamon, Matthew A Parker, Stephen J Howard, Hari Krishna Santhapuram, Apparao Satyam, Joseph Anand Reddy: Vitamin receptor binding drug delivery conjugates. Endocyte, Barnes & Thornburg, October 13, 2009: US07601332 (42 worldwide citation)

The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding ana ...


4
Leamon Christopher Paul, Wang Yu, Vlahov Iontcho Radoslavov, You Fei, Kleindl Paul Joseph, Santhapuram Hari Krishna R: Conjugates containing hydrophilic spacer linkers. Endocyte, Leamon Christopher Paul, Wang Yu, Vlahov Iontcho Radoslavov, You Fei, Kleindl Paul Joseph, Santhapuram Hari Krishna R, BALL Rebecca L, December 31, 2008: WO/2009/002993 (38 worldwide citation)

Described herein are compositions and methods for use in targeted drug delivery using cell- surface receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations.


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Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Satyam Apparao, Howard Stephen J: Bivalent linkers and conjugates thereof. Endocyte, Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Satyam Apparao, Howard Stephen J, BALL Rebecca L, February 2, 2006: WO/2006/012527 (36 worldwide citation)

Bivalent linkers derived from compounds of formulae (V), (VI) and (VII), where X1 and X2 are leaving groups and the other variables are as defined in the claims, to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.


6
Xu Le Cun, Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Santhapuram Hari Krishna, Li Chunhong: Synthesis and purification of pteroic acid and conjugates thereof. Endocyte, Xu Le Cun, Vlahov Iontcho Radoslavov, Leamon Christopher Paul, Santhapuram Hari Krishna, Li Chunhong, ADDISON Bradford G, September 28, 2006: WO/2006/101845 (32 worldwide citation)

Methods for purifying pteroic acid, analogs of pteroic acid, and derivatives of pteroic acid are described. Methods for synthesizing and purifying conjugates of vitamins, including FITC conjugates of folic acid, folic acid analogs, and derivatives of folic acid and folic acid analogs are also descri ...


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Lemaon Christopher Paul, Vlahov Iontcho Radoslavov: Ligand conjugates of vinca alkaloids, analogs, and derivatives. Endocyte, Lemaon Christopher Paul, Vlahov Iontcho Radoslavov, ADDISON Bradford G, February 22, 2007: WO/2007/022493 (29 worldwide citation)

Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of cytotoxic drugs and vitamin receptor binding ligands. The conjugates also include a linker that is formed from one or mo ...


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Low Philip Stewart, Hartmann Lynn C, Leamon Christopher Paul, Ellis Phil Ronald: Method for cancer prognosis using cellular folate vitamin receptor quantification. Purdue Research Foundation, Endocyte, Mayo Foundation For Medical Education And Research, Low Philip Stewart, Hartmann Lynn C, Leamon Christopher Paul, Ellis Phil Ronald, ADDISON Bradford G, October 5, 2006: WO/2006/105141 (23 worldwide citation)

The invention relates to a method for determining a prognosis for a cancer by quantifying vitamin receptor expression on the cancer cells. The method comprises the steps of quantifying vitamin receptor expression on the cancer cells, and determining a prognosis for the cancer. The invention also rel ...


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Vlahov Iontcho Radoslavov, Leamon Christopher Paul: Multi-drug ligand conjugates. Endocyte, Vlahov Iontcho Radoslavov, Leamon Christopher Paul, ADDISON Bradford G, February 22, 2007: WO/2007/022494 (23 worldwide citation)

Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of a plurality of cytotoxic drugs and vitamin receptor binding ligands. The plurality of drugs may be the same or different ...


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Leamon Christopher Paul, Vlahov Lontcho Radoslavov: Methods and compositions for treating and diagnosing kidney disease. Endocyte, Leamon Christopher Paul, Vlahov Lontcho Radoslavov, BALL Rebecca L, August 21, 2008: WO/2008/101231 (20 worldwide citation)

The invention relates to a method for diagnosing a kidney disease state. The method comprises the steps of administering to a patient a composition comprising a conjugate or complex of the general formula V-L-D where the group V comprises a vitamin receptor binding ligand that binds to kidney proxim ...