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Miyazaki Kazuki, Kusano Kazutomi, Takase Yasutaka, Asano Osamu, Shirato Manabu, Wakita Hisashi, Ishii Naoto, Saeki Takao: 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivative. Eisai R&Amp Amp D Management, October 24, 2008: KR1020087021869

A compound represented by the formula (I) below, a salt thereof or a hydrate of any of them is capable of effectively suppressing itch of atopic diseases and the like. (I) [In the formula, R represents a hydroxyl group, a C1-6 alkoxy group which may be substituted by a C1-6 alkoxy group, or an ...


2
Negi Shigeto, Shimizu Toshikazu, Kuroda Hiroshi, Shimomura Naoyuki, Sasho Manabu, Hoshino Yorihisa, Kubota Manabu: Process for production of pyrazole-fused ring derivatives. Eisai R&Amp Amp D Management, January 31, 2007: KR1020067021332

The invention aim at finding intermediates useful in the synthesis of pyrazole-fused ring derivatives (such as 7-phenylpyrazolo[1,5-a]pyridine derivatives) and a process for the production thereof. A process for the production of compounds represented by the general formula (II), salts the ...


3
Furitsu Hisao, Suzuki Yasuyuki: Medicinal composition. Eisai R&Amp Amp D Management, May 23, 2007: KR1020077001347

A medicinal composition which comprises: a medicinal ingredient comprising, e.g., 4-(3-chloro-4-(cyclopropylamino-carbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, a salt thereof, or a solvate of either; and (i) a compound whose 5% (w/w) aqueous solution or dispersion has a pH of 8 or higher ...


4
Owa Takashi, Yokoi Akira, Kuromitsu Junro, Kawai Takatoshi, Kato Hiroyuki, Nagasu Takeshi: Method of testing anticancer agent-sensitivity of tumor cells. Eisai R&Amp Amp D Management, March 24, 2008: KR1020087004808

Tumor cells are taken out from cancer patients to which anticancer agents (E7070 and analogous compounds) have been administered and then the expression doses of the genes listed in Tables 3 and 4 are measured. Alternatively, tumor cells taken out from cancer patients are treated with anticancer age ...


5
Matsushima Tomohiro, Nakamura Taiju, Yoshizawa Kazuhiro, Kamada Atsushi, Ayata Yusuke, Suzuki Naoko, Arimoto Itaru, Sakaguchi Takahisa, Gotoda Masaharu: (cyclopropylaminocarbonyl)Amino-phenoxy)- 7-methoxy-6-quinolinecarboxamide or of solvate thereof and processes for producing these. Eisai R&Amp Amp D Management, March 31, 2008: KR1020087005282

Crystals of the hydrochloride, hydrobromide, p-toluenesulfonate, sulfate, methanesulfonate, or ethanesulfonate of 4-(3-chloro-4- (cyclopropylamino-carbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide or crystals of a solvate of any of these.


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Machida Kazuhiro, Nakashima Takashi, Aritoku Yasuhide, Tsuchida Toshio: Dna participating in hydroxylation of macrolide compound. Eisai R&Amp Amp D Management, October 25, 2006: KR1020067006995

It is intended to provide a DNA participating in the hydroxylation of a macrolide compound 11107B and a novel method of producing a macrolide compound 11107D. More specifically speaking, a DNA participating in the biological conversion of the macrolide compound 11107B represented by the formula (I) ...


7
Nagato Satoshi, Ueno Kohshi, Kawano Koki, Norimine Yoshihiko, Ito Koichi, Hanada Takahisa, Ueno Masataka, Amino Hiroyuki, Ogo Makoto, Hatakeyama Shinji, Urawa Yoshio, Naka Hiroyuki, Groom Anthony John, Rivers Leanne, Smith Terence: 1,2-dihydropyridine compounds, process for preparation of the same and use thereof. Eisai R&Amp Amp D Management, September 27, 2007: KR1020077020877

Provided are novel compounds exhibiting excellent inhibitory activities against AMPA receptor and/or kainite receptor, specifically compounds of the general formula (I), salts of the same, or hydrates of both, wherein Q is NH, O, or S; and R1, R2, R3, R4 and R5 are each independently hydrogen, halog ...


8
Nagato Satoshi, Ueno Kohshi, Kawano Koki, Norimine Yoshihiko, Ito Koichi, Hanada Takahisa, Ueno Masataka, Amino Hiroyuki, Ogo Makoto, Hatakeyama Shinji, Urawa Yoshio, Naka Hiroyuki, Groom Anthony John, Rivers Leanne, Smith Terence: 1,2-dihydropyridine compounds, process for preparation of the same and use thereof. Eisai R&Amp Amp D Management, September 27, 2007: KR1020077020875

Provided are novel compounds exhibiting excellent inhibitory activities against AMPA receptor and/or kainite receptor, specifically compounds of the general formula (I), salts of the same, or hydrates of both, wherein Q is NH, O, or S; and R1, R2, R3, R4 and R5 are each independently hydrogen, halog ...


9
Nakajima Toshihiro, Amano Tetsuya, Zhang Lei, Ikeda Rie, Yamasaki Satoshi, Yagishita Naoko, Yokohama Hiromitsu, Kogushi Motoji: Method of detecting effect of controlling synoviolin activity. Locomogene, Eisai R&Amp Amp D Management, April 27, 2006: KR1020067003391

It is intended to provide a method for evaluating an effect of controlling the activity of proline 4-hydroxyolase; a screening method with the use of the above evaluation method; and a method of screening a compound which is useful in treating or preventing fibrosis or rheumatoid arthritis. A method ...


10
Yatsuhashi Hiroshi, Akiyama Masanori, Matsumoto Takehiro: Method of creating disease prognosis model, method of predicting disease prognosis using the model, device for predicting disease prognosis using the model, its program, and recording medium. Eisai R&Amp Amp D Management, Yatsuhashi Hiroshi, Akiyama Masanori, February 1, 2006: KR1020057020055

A model for predicting the prognosis of a predetermined disease from laboratory chemical examination values is created using a computer. Multiple laboratory chemical examination measured values of the disease and measured values of the prognosis are entered in a computer and processed by a data-mini ...