1
Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Yuoichi, Sasaki Atsushi, Yamanashi Yoshiharu, Ogura Hiroo, Araki Shin Kashiwa Mansion, Kosasa Takashi, Kusota Atsuhiki, Kozasa Michiko, Yamatsu Kiyomi: Cyclic amine compound, its use and pharmaceutical compositions comprising it.. Eisai, December 28, 1988: EP0296560-A2 (141 worldwide citation)

A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-( ...


2
Takase Yasutaka, Watanabe Nobuhisa, Matsui Makoto, Ikuta Hironori, Kimura Teiji, Saeki Takao, Adachi Hideyuki, Tokumura Tadakazu, Mochida Hisatoshi, Akita Yasunori, Souda Shigeru: Nitrogenous heterocyclic compound.. Eisai, July 27, 1994: EP0607439-A1 (120 worldwide citation)

A nitrogenous heterocyclic compound represented by general formula (I) or a pharmacologically acceptable salt thereof, efficacious in treating various ischemic cardiac diseases, wherein ring A represents a benzene, pyridine or cyclohexane ring; ring B represents a pyridine, pyrimidine or imidazole r ...


3
Hachiro Sugimoto, Yutaka Tsuchiya, Kunizou Higurashi, Norio Karibe, Youichi Iimura, Atsushi Sasaki, Yoshiharu Yamanishi, Hiroo Ogura, Shin Araki, Takashi Kosasa, Atsuhiko Kubota, Michiko Kosasa, Kiyomi Yamatsu: Cyclic amine compounds with activity against acetylcholinesterase. Eisai, Flynn Thiel Boutell & Tanis, January 23, 1990: US04895841 (111 worldwide citation)

A cyclic amine compound is defined by the formula: ##STR1## in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is --(CHR22)r--, R22 being H or methyl, --CO--(CHR22)r--, .dbd.( ...


4
Akinobu Watanabe: Aqueous bactericide for animal treatment. Eisai, Daicel Chemical, Flynn Thiel Boutell & Tanis, March 3, 1992: US05093140 (86 worldwide citation)

A process for treating animal meat during the steps of scalding and chilling is disclosed. The meat is treated with an aqueous Biocide which contains a mixture of two or more organic acids and a surfactant.


5
Yasuhiro Funahashi, Akihiko Tsuruoka, Masayuki Matsukura, Toru Haneda, Yoshio Fukuda, Junichi Kamata, Keiko Takahashi, Tomohiro Matsushima, Kazuki Miyazaki, Ken ichi Nomoto, Tatsuo Watanabe, Hiroshi Obaishi, Atsumi Yamaguchi, Sachi Suzuki, Katsuji Nakamura, Fusayo Mimura, Yuji Yamamoto, Junji Matsui, Kenji Matsui, Takako Yoshiba, Yasuyuki Suzuki, Itaru Arimoto: Nitrogen-containing aromatic derivatives. Eisai, Andrea L C Robidoux, Choate Hall & Stewart, August 7, 2007: US07253286 (78 worldwide citation)

Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a grou ...


6
Seiji Yoshikawa, Eita Emori, Fumiyoshi Matsuura, Richard Clark, Hironori Ikuta, Nobuyuki Yasuda, Tadashi Nagakura, Kazuto Yamazaki, Mika Aoki: Xanthine derivative and DPPIV inhibitor. Eisai, Townsend and Townsend and Crew, July 11, 2006: US07074798 (76 worldwide citation)

The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, and R42 each represent a hydrogen atom; X represents an alkynyl group, an ...


7

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Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Clark Richard, Ikuta Hironori, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, Aoki Mika: Xanthine derivatives as dpp-iv inhibitors. Eisai, August 27, 2003: EP1338595-A2 (68 worldwide citation)

The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R, R, R, R, R, R, R, R, R, R, R, and R each represent a hydrogen atom; X represents an alkynyl group, an aryl group, and such, w ...


9
Miyake Kazutoshi, Matsukura Masayuki, Yoneda Naoki, Hiroshima Osamu, Mori Nobuyuki, Ishihara Hiroki, Musha Takashi, Matsuoka Toshiyuki, Hamano Sachiyuki, Minami Norio: Biphenylmethane derivative, the use of it and pharmacological compositions containing same.. Eisai, April 3, 1991: EP0420237-A1 (67 worldwide citation)

The biphenylmethane derivative having the formula (I) is disclosed in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, -S-R7, -SO2-R7, -C IDENTICAL C-R7 or -(CH2)p-OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, -A1=A2-A3=A4- is -CH=CH-CH=C ...


10
Yasutaka Takase, Nobuhisa Watanabe, Makoto Matsui, Hironori Ikuta, Teiji Kimura, Takao Saeki, Hideyuki Adachi, Tadakazu Tokumura, Hisatoshi Mochida, Yasunori Akita, Shigeru Souda: Benzimidazoles for ischemic heart conditions. Eisai, Nixon & Vanderhye, December 2, 1997: US05693652 (66 worldwide citation)

The present invention provides a nitrogenous heterocyclic compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof which is useful for various ischemic heart diseases and the like: ##STR1## �in formula (1), ring A represents a benzene ring, a pyridine ...