1
Djuric Stevan Wakefield, Docter Stephen Hermann, Yu Stella Siu Tzyy: Leukotriene b¿4? antagonists. Gd Searle & Co, Djuric Stevan Wakefield, Docter Stephen Hermann, Yu Stella Siu Tzyy, sWILLIAMS Roger A, January 9, 1992: WO/1992/000011 (11 worldwide citation)

This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl; R?1¿ is alkyl; R?2¿ is hydrogen or alkyl; R?6¿ is alkyl; n is 1 to 5; p is 0 to 6; x is 0 or 2; and R?4¿ and R?5¿ are inde ...


2
Djuric Stevan Wakefield, Yu Stella Siu Tzyy: Leukotriene b¿4? antagonists. Gd Searle & Co, Djuric Stevan Wakefield, Yu Stella Siu Tzyy, sFEDER Scott B, December 14, 1995: WO/1995/033742

This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl; R?1¿ is alkyl; R?2¿ represents alkyl from 1 to 5 carbon atoms, aryl or aryl substituted with halogen or alkyl from 1 to 5 ...


3
Djuric Stevan Wakefield, Penning Thomas Dale: Alkoxy-substituted dihydrobenzopyran-2-sulfonimides derivatives, their preparation and their use as leukotriene b4 antagonists. Gd Searle & Co, Djuric Stevan Wakefield, Penning Thomas Dale, sFEDER Scott B, November 30, 1995: WO/1995/032201

This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R represents alkyl having 2 to 6 carbon atoms, alkenyl having 2 to 6 carbon atoms, alkynyl having 2 to 6 carbon atoms, or -(CH¿2?)¿m?-R?3¿ wherein R?3¿ represents cycloalky ...


4
Djuric Stevan Wakefield, Penning Thomas Dale: Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof. Gd Searle & Co, Djuric Stevan Wakefield, Penning Thomas Dale, sWILLIAMS Roger A, November 28, 1991: WO/1991/017989

This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl and m is 1 or 2; R?1¿ is alkyl of 1 to 4 carbon atoms; R?2¿ is hydrogen or alkyl of 1 to 5 carbon atoms; R?4¿ is alkyl of 1 ...


5
Djuric Stevan Wakefield, Penning Thomas Dale, Snyder James Patrick: Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof. Gd Searle & Co, Djuric Stevan Wakefield, Penning Thomas Dale, Snyder James Patrick, sWILLIAMS Roger A, November 14, 1991: WO/1991/017160

This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R is alkyl, alkenyl, alkynyl, or (CH¿2?)¿m? R?3¿ where R?3¿ is cycloalkyl and m is 1 or 2; R?1¿ is alkyl; R?2¿ is hydrogen or alkyl; R?4¿ is alkyl; n is an interger from 1 ...


6
Djuric Stevan Wakefield, Haack Richard Arthur, Miyashiro Julie Marion: Ltb4 synthesis inhibitors. G D Searle & Co, Djuric Stevan Wakefield, Haack Richard Arthur, Miyashiro Julie Marion, sKOVACEVIC Cindy S, December 10, 1992: WO/1992/021644

This invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, -CH=CH-, or -CH=N-; wherein R?1¿ is -CO¿2?R?2¿ or tetrazole; wherein R?2¿ is hydrogen, alkyl of 1 to 6 carbons or a pharmaceutically acceptable cation; wherein R is an alky ...


7
Djuric Stevan Wakefield, Docter Stephen H, Haack Richard Arthur: Pla¿2? inhibitors. G D Searle & Co, Djuric Stevan Wakefield, Docter Stephen H, Haack Richard Arthur, sKOVACEVIC Cynthia S, December 10, 1992: WO/1992/021672

This invention relates to novel compounds for treating inflammatory conditions by inhibition of phospholipase A¿2? activity of formula (I) wherein X is oxygen, sulfur or -CH=CH-; wherein R?1¿ is hydrogen, alkyl of 1 to 6 carbons or a pharmaceutically acceptable cation; wherein R?2¿ is phenoxy, alkox ...


8
Djuric Stevan Wakefield, Fretland Donald John, Yu Stella Siu Tzyy: Anti-inflammatory compounds. Gd Searle & Co, Djuric Stevan Wakefield, Fretland Donald John, Yu Stella Siu Tzyy, sWILLIAMS Roger A, July 9, 1992: WO/1992/011252

This invention encompasses compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof. In formula (I) R represents lower alkyl of 1 to 6 carbon atoms, lower alkenyl of 2 to 6 carbon atoms, or -(CH¿2?)¿m?-R?3¿ wherein R?3¿ represents cycloalkyl of 3 to 5 carbon atoms ...


9