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Brown Matthew Lee, Cheung Mui, Dickerson Scott Howard, Gauthier Cassandra, Harris Philip Anthony, Hunter Robert Neil Iii, Pacofsky Gregory, Peel Michael Robert, Stafford Jeffrey Alan: Chemical compounds. Smithkline Beecham Corporation, Brown Matthew Lee, Cheung Mui, Dickerson Scott Howard, Gauthier Cassandra, Harris Philip Anthony, Hunter Robert Neil Iii, Pacofsky Gregory, Peel Michael Robert, Stafford Jeffrey Alan, LEVY David J, April 22, 2004: WO/2004/032882 (14 worldwide citation)

Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.


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Dickerson Scott Howard, Tavares Francis Xavier, Zhou Huiqiang: Pyradazine compounds as gsk-3 inhibitors. Smithkline Beecham Corporation, Dickerson Scott Howard, Tavares Francis Xavier, Zhou Huiqiang, LEVY David J, April 29, 2004: WO/2004/035588 (10 worldwide citation)

The present invention relates generally to inhibitors of the kinases, such as GSK3, and more particularly to fused pyradazine compounds according to formula (I) and methods of their use.


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